Grave''''s病患者血清IAA、ICA、GADA的测定及意义

目的测定Graves病患者血清中IAA、ICA、GADA的水平并进一步探讨其意义。方法2003-2004年在我院新诊断的c嗍病患者54例，分别测定患者空腹血糖、OGTT 2h血糖，并以ELISA方法测定其血清IAA、ICA、GADA。结果54例Graves病患者中检出糖耐量减退（IGT）患者8例，糖尿病（DM）患者3例。IAA、ICA、GADA阳性率分别为3．7％、9．26％、11．1％。结论ICA、GADA与Graves病有关，但不是病人出现血糖异常的主要原因。

The level and clinical implication of antibodies to insulin、 islet cell and glutamic acid decarboxylase in patients with Graves disease

Objective To investigate the level and clinical implication of antibodies to insulin, islet cell and glutamic acid decarboxylase in patients with Graves disease. Methods 54 patients with Graves disease were diagnosed for the first time. Their fasting plasma glucose and Oral Glucose Tolerance Test 2h plasma glucose were test and that ELISA was used to determine the levels of IAA, ICA and GADA. Results 8 patients with impaired glucose tolerance and 3 patients with diabetes were diagnosed. The ratios of Graves disease patients with positive 1AA,ICA and GADA were 3.7 % ,9.26% and 11.1%. Conclusion ICA and GADA were related to Graves disease, but no relations were seen between ICA, GADA and their abnormal plasma glucose.