Effects of Chinese Materia Medica-Fubao Danggui Jiao on experimental endometriosis |
| |
Authors: | Sun Xing Chen Lijue Zeng Fanbo |
| |
Affiliation: | Department of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. sunxing10wy@yahoo.cn |
| |
Abstract: | The objective of this paper was to investigate the effects of a Chinese Materia Medica variant -Fubao Danggui Jiao (FDJ)-on experimental endometriosis. An endometriosis model was created by virtue of auto-transplantation of endometrial tissue onto rats' abdominal walls. The implants were allowed to grow for 30 days until the successful completion of the model. After that, forty endometriotic rats were randomly divided into four study groups and given different treatments: (1) negative control group (water, 2ml/kg, per os); (2) FDJ-A group (FDJ, 2ml/kg, per os); (3) FDJ-B group (FDJ, 4ml/kg, per os); (4) Danazol group (70mg/kg, per os). After 30 days with treatments, the volumes of endometriotic implants in each rat were measured. The implants and normal uterine horns were removed for routine histological examination. FDJ caused significant decreases in volumes of the surviving endometriotic implants, with two different doses having statistically equivalent effects. Upon histological examination, FDJ was observed to cause regression of epithelium and stroma of endometriotic implants. FDJ had revealed promising therapeutic effects on endometriosis. |
| |
Keywords: | Fubao Danggui Jiao Chinese Materia Medica Endometriosis Danazol |
本文献已被 PubMed 等数据库收录! |
|