高敏C反应蛋白与IL-6水平变化在AECOPD早期诊断中的价值及特异性分析

目的：研究高敏C反应蛋白与IL-6水平变化在AECOPD早期诊断中的价值及特异性。方法：选取我院收治的急性加重期慢性阻塞性肺疾病(AECOPD)患者共计78例作为观察组进行研究,另选取78例同期于我院接受治疗的COPD患者作为对照组。所有患者在入院后均采取祛痰、抗感染、氧疗以及平喘治疗。观察并比较两组患者的CRP、IL-6水平变化情况、不同程度病情患者血清CRP、IL-6水平变化情况以及CRP与IL-6诊断AECOPD的特异性和敏感性,分析CRP与IL-6水平变化与病情的关系。结果：两组患者治疗后的血清CRP、IL-6水平较治疗前均明显下降,同时,观察组患者血清CRP、IL-6水平治疗前后均明显高于对照组,与对照组和治疗前比较均存在统计学意义(P<0.05)。重度患者患者治疗后血清CRP、IL-6水平仍高于轻、中度患者,数据差异具有统计学意义(P<0.05)。同程度患者治疗后的血清CRP、IL-6水平较治疗前明显降低,两组比较具有显著性差异(P<0.05)。IL-6诊断的特异性明显高于CRP,且CRP与IL-6联合检测诊断的特异性高于单独诊断的特异性(P<0.05)。结论：血清CRP和IL-6均属于敏感指标且参与了患者疾病的发生、进展,对AECOPD患者进行检测不仅可以判断患者疾病严重程度,两者联合检测还可提高敏感性和特异性,在对患者早期诊断中具有较为重要的临床意义。

The Value and specificity of high sensitivity C-reactive protein and IL-6 in early diagnosis of AECOPD

Objective:To study value and specificity of high sensitivity C-reactive protein and IL-6 in early diagnosis of AECOPD. Methods: A total of 78 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) admitted to our hospital were selected as the observation group. Another 78 patients with COPD who were treated in our hospital during the same period were selected as the control group. All patients after admission to take expectorant, anti-infective, oxygen therapy and asthma treatment. They were compared with changes of CRP, IL-6 level, the levels of serum CRP and IL-6 in patients with different degrees of disease, specificity and sensitivity of CRP and IL-6 in diagnosing AECOPD, and to analyze the relationship between CRP and IL-6 levels and the disease.Results: The levels of serum CRP and IL-6 in two groups of patients were significantly lower than those before treatment, the levels of serum CRP and IL-6 in the observation group were significantly higher than those in the control group before and after treatment (P <0.05). Serum levels of CRP and IL-6 in patients with severe disease were still higher than those in patients with mild to moderate disease, the difference was statistically significant (P <0.05). The levels of serum CRP and IL-6 in patients with the same degree of treatment were significantly lower than those before treatment (P <0.05). The diagnostic specificity of IL-6 was significantly higher than that of CRP, and the specificity of combined detection of CRP and IL-6 was higher than that of single diagnosis (P <0.05). Conclusion: Serum CRP and IL-6 are sensitive indicators and involved in the occurrence and progressof disease, the detection of AECOPD patients can not determine the severity of disease in patients. The combination of the two can also improve the sensitivity and specificity, in the early diagnosis of patients with a more important clinical significance.