| 肥胖患者血清单核细胞趋化蛋白1浓度与葡萄糖钳夹试验胰岛素敏感性的关系 |
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| 引用本文： | 李佳,陈秋,姜鲜. 肥胖患者血清单核细胞趋化蛋白1浓度与葡萄糖钳夹试验胰岛素敏感性的关系[J]. 中华内分泌代谢杂志, 2009, 25(5). DOI: 10.3760/cma.j.issn.1000-6699.2009.05.016 |
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| 作者姓名： | 李佳 陈秋 姜鲜 |
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| 作者单位： | 1. 泸州医学院附属医院内分泌科,646000
2. 泸州医学院附属医院麻醉科,646000 |
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| 摘 要： | 血清单核细胞趋化蛋白1(MCP-1)浓度随正常人[(65.6±17.7)ng/L]、体重指数＞25 kg/m2的糖耐量正常者[(136.8±57.4)ng/L]和超重或肥胖的2型糖尿病患者逐步升高[(189.4±72.1)ng/L,均P＜0.01],胰岛素介导的葡萄糖代谢率(Rd)则降低[(10.66±1.68,6.11±2.06,4.86±1.38)mg·kg-1·min-1,P＜0.05或P＜0.01].部分2型糖尿病患者(n=13)经12周罗格列酮治疗后,MCP-1降低[(113.0±35.7vs186.9±64.3)ng/L,P＜0.01],Rd升高[(6.34±1.18vs4.97±1.51)mg·kg-1·min-1,P＜0.01].
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| 关 键 词： | 单核细胞趋化蛋白1 糖尿病 2型 胰岛素抵抗 罗格列酮 |
Relationship between serum monocyte chemoattractant protein-1 concentration and insulin sensitivity by glucose clamp in obese patients |
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| Abstract: | Serum monocyte chemoattractant protein-1 ( MCP-1) was increased progressively in healthy, obese(body mass index>25 kg/m2) subjects,and obese type 2 diabetic patients[ (65.6±17.7,136.8±57.4 and 189.4±72.1) ng/L,all P<0.01 ],while insulin-mediated glucose disposal ( Rd) was decreased[ (10.66±1.68, 6.11 ±2.06 and 4.86±1.38)mg · kg-1 · min-1,P<0.05 or P<0.01].After 12-week treatment with rosiglitazone, MCP-1 was decreased[ (113.0±35.7 vs 186.9±64.3)ng/L,P<0.01 ] and Rd increased[ (6.34±1.18 us 4.97± 1.51)mg·kg-1 · min-1,P<0.01]. |
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| Keywords: | Monocyte chemoattractant protein-1 Diabetes mellitus,type2 Iusulin resistance Rosiglitazone |
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