枢复宁控制骨肿瘤化疗及对生存质量的影响

目的采用自身对照方法观察60例骨肿瘤患者应用枢复宁及枢复宁加地塞米松控制化疗对生存质量的影响。方法病人为接受HD-MTX-CFR化疗的住院病人,均在第1天给药。A组第1周期用单剂枢复宁,第2周期为地塞米松和枢复宁联合应用;B组与A组相反。结果枢复宁和地塞松联合应用控制化疗后d1急性呕吐有效率为95%,患者平均呕吐时间为14分,VAS平均为19mm,优于枢复宁单剂用药(P<0.05)。两组生存质量联合用药组明显高于单用枢复宁组(P<0.05)。对于迟发性呕吐(第3～5天)及副反应两者没有显著差异(P>0.05)。结论枢复宁和地塞米松联合应用可以有效地提高枢复宁控制化疗所致的胃肠道反应的疗效;改善肿瘤化疗患者的生存质量。

Prerention of anticancer drugs induced emesis: a self- comparision study on ondansetrion and dexamethasone

Objective A self-comparision study on the effi cacy of ondansetron(OND)and dexamethasone(DEX)during chemotherapy induced gaslroenteric reaction was conducted in 60patients.Methods They were randomised to receive eith er OND or OND plus DEX.Before the first circle of chemotherapy,an d crossed-cover to the other anti-em etic agent in the second circle of the same chemotherapy.Results Effextive protection in the first day from emsis /nausea was obtained in 40/60patients(67%)with OND and in 57/60(95%)with OND plus DEX(P<0.05),mean durtation of emesis(72minutes and 14minutes,P<0.05),mean VAS(32mmv 19min)were also significantly decreased in OND plus DEX group compared with OND group.Side effects were very mild and not significants diffe rent between the two treatments.Conclusion OND plus DEX is more efficacious than OND in protecting bone tumor patient s from chemotherapy induced emesis a nd nausea.