| 吡喹酮抗血吸虫作用的研究进展 |
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| 引用本文： | 肖树华. 吡喹酮抗血吸虫作用的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2007, 25(6): 492-502 |
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| 作者姓名： | 肖树华 |
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| 作者单位： | 中国疾病预防控制中心寄生虫病预防控制所,世界卫生组织,疟疾、血吸虫病和丝虫病合作中心,上海,200025 |
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| 摘 要： | 吡喹酮是目前惟一对人体5种血吸虫病均有效的治疗药物，其突出优点是口服方便、安全有效和疗程短。了解其抗血吸虫的作用机制，可能有益于发展新的广谱抗蠕虫药物。本文综述了近30年来国、内外实验室对吡喹酮抗血吸虫作用的研究进展。
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| 关 键 词： | 吡喹酮 血吸虫 作用方式 |
| 文章编号： | 1000-7423（2007）-06-0492-11 |
| 收稿时间： | 2007-01-05 |
| 修稿时间： | 2007-01-05 |
Study Progress on the Mode of Action of Praziquantel Against Schistosomes |
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| XIAO Shu-hua. Study Progress on the Mode of Action of Praziquantel Against Schistosomes[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2007, 25(6): 492-502 |
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| Authors: | XIAO Shu-hua |
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| Affiliation: | National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China. |
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| Abstract: | Praziquantel is the only effective drug of choice against five huaman species of schistosomes. Main advantages of praziquantel include convenient oral administration, high safety and efficacy as well as short treatment course. To better understand the mode of action of praziqantel against schistosomes would be helpful for further development of new broad-spectrum anthelminthics. This paper summarizes the 30 years' research progress on the mode of action of the drug against schistosomes proceeded by domestic and abroad laboratories. |
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| Keywords: | Praziquanel Schistosome Mode of action |
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