升高的血清中性粒细胞/淋巴细胞比值与肝内胆管癌较差的预后有关

目的探讨术前血清炎症指标与肝内胆管癌预后之间的关系。方法回顾性分析接受R0肝切除治疗的382例肝内胆管癌患者的临床病理资料,应用最小P值法确定炎症指标截断值,将每个炎症指标分为高低两组。应用KaplanMeier法描绘生存和复发曲线,Cox回归模型分析影响其预后的因素。结果 NLR(中性粒细胞数/淋巴细胞数)≥2.30是ICC患者术后总体生存和肿瘤复发的独立危险因素。NLR≥2.30的患者其血清癌胚抗原水平较高,肿瘤直径较大、多发肿瘤比例高、淋巴转移和血管侵犯比例大。结论 NLR≥2.30是肝内胆管癌患者预后的独立危险因素,NLR≥2.30的患者其术后总体生存率较差,肿瘤复发率更高。

Elevated serum neutrophils-lymphocyte ratio predicts a worse prognoses in intrahepatic cholangiocarcinoma after liver resection

Objective To explore the association between preoperative serum inflammatory markers and prognosis in intrahepatic cholangiocarcinoma (ICC) patients underwent liver resection.Methods Data of 382 consecutive ICC patients who underwent hepatectomy were retrospectively reviewed.The cut-off values of inflammation marker were calculated by using the minimum P value method.The curves of overall survival and tumor recurrence were depicted using the Kaplan-Meier method and compared using the logrank test.Independent risk factors of OS and tumor recurrence were analyzed with the Cox hazard regression model.Results NLR (neutrophil count divided by lymphocyte count) ≥ 2.30 was an independent risk factor of overall survival and tumor recurrence (Hazard Ratio [HR]:1.326,95％ Confidence Interval [CI]:1.105-1.593;1.270,1.071-1.506).Patients with a NLR ≥ 2.30 had higher CEA levels,larger tumor size,more tumor nodes,more lymph node metastasis and vascular invasion.Conclusions Inflammatory markers NLR ≥ 2.30 is an independent risk factor of prognosis,which predicted a worse prognosis of ICC patients who underwent resection.