Assessment of Equine Autoimmune Thrombocytopenia (EAT) by flow cytometry |
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Authors: | Rafael Nunez M Alice Gomes-Keller Colin Schwarzwald Karsten Feige |
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Affiliation: | (1) Institutes of Virology, University of Zurich, Zurich, Switzerland;(2) Department of Internal Medicine, University of Zurich, Zurich, Switzerland;(3) Clinical Laboratory, University of Zurich, Zurich, Switzerland;(4) Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, USA |
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Abstract: | Rationale Thrombocytopenia is a platelet associated process that occurs in human and animals as result of i) decreased production; ii) increased utilization; iii) increased destruction coupled to the presence of antibodies, within a process know as immune-mediated thrombocytopenia (IMT); or iv) platelet sequestration. Thus, the differentiation of the origin of IMT and the development of reliable diagnostic approaches and methodologies are important in the clarification of IMT pathogenesis. Therefore, there is a growing need in the field for easy to perform assays for assessing platelet morphological characteristics paired with detection of platelet-bound IgG. |
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