Innate responses of B cells |
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Authors: | Gray David Gray Mohini Barr Tom |
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Affiliation: | Institute of Immunology and Infection Research, University of Edinburgh, Ashworth Labs, Edinburgh, UK. d.gray@ed.ac.uk |
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Abstract: | In this review, we describe the non-antibody-mediated functions of B cells within the immune system. In addition to antibody production, B cells also present antigen to T cells, programme T cell differentiation and regulate effector T cell responses and much of this is mediated by the cytokines they make. We focus on the potential of B cells to perform these functions simply as a result of activation via 'innate' receptors (e.g. Toll-like receptors) and often independently of BCR ligation. We feel an appreciation of these broad and often antigen-nonspecific functions is important at a time when there is an increasing use of B cell depletion as a therapy for autoimmune disease. |
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Keywords: | Antigen presenting cells B lymphocytes Cytokines Innate immunity Toll‐like receptors |
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