Effects of risperidone on glucose metabolism in Chinese patients with schizophrenia: a prospective study |
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Authors: | Chen Qi Cai Zhuo-Ji Mao Pei-Xian Zhai Yi-Ming Mitchell Philip B Tang Yi-Lang |
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Institution: | a Department of General Psychiatry, Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China b Laboratory of Therapeutic Drug Monitor, Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China c Department of Human Genetics and Psychiatry and Human Behaviors, Emory University School of Medicine, 615 Micheal Street, Suite 301, Atlanta, GA 30322, USA d School of Psychiatry, University of New South Wales and Black Dog Institute, Sydney, Australia |
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Abstract: | BackgroundWhile most of the second generation antipsychotic agents are associated with abnormal glucose metabolism, previous studies have shown that risperidone has relatively little effect upon blood glucose levels. This study aimed to explore the effect of risperidone on the glucose-regulating mechanism of patients with schizophrenia by using the oral glucose tolerance test (OGTT), measuring insulin and C-peptide levels.MethodsThirty inpatients with schizophrenia taking risperidone were studied. All the patients were given a simplified OGTT at baseline and six weeks after treatment. Plasma glucose, insulin, and C-peptide concentrations were measured at fasting, then 1 and 2 h after OGTT respectively. Other data, including demographic characteristics and plasma drug concentrations, were also recorded.Results(1) There was no significant increase in the proportion of patients demonstrating abnormal plasma glucose levels compared with baseline (p = 1.000, McNemar test); (2) risperidone was associated with elevated insulin concentrations (p = 0.013), C-peptide levels (p = 0.020), insulin/glucose ratio (p = 0.020) and BMI (p < 0.01); (3) no sex differences in glucose-related measures were observed.ConclusionRisperidone treatment may be associated with alterations in glucose-regulating mechanisms in patients with schizophrenia. |
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Keywords: | Risperidone Oral glucose tolerance test Insulin C-peptide Chinese race Schizophrenia Sex |
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