血清γ-微球蛋白C测定的临床应用及初步评价

目的 评价γ—微球蛋白C(CystatinC)的临床应用价值。方法 采用胶乳颗粒增强免疫散射浊度法，测定健康成人、儿童及肾脏疾病患者的血清CystatinC水平、血清肌酐和肌酐清除率。结果 血清CyshtinC在出生后早期平均水平是成人的2倍，l～60岁维持在lmg/L以下，60岁后呈逐渐升高的趋势。各种肾脏病患者的血清CystatinC与肌酐之间有显著正相关；肌酐清除率的对数值与CystatinC和肌酐的对数值均呈显著负相关，肌酐清除率异常时，CystatinC比肌酐有更高的符合率。结论 血清CystatinC是较敏感的肾小球滤过功能指标，适合儿童、老年人等不能准确留尿的患者及需连续监测肾滤过功能的各种患者。

The practical use of serum Cystatin C measurement and its initial evaluation

Objective To evaluate value of cystatin C in clinical utilization.Methods An automated particle enhanced nephelometric immunoassay was used to measure concentration of serum cystatin C on Behring Nephelometer 100.Totally 72 cases of healthy adults and 63 cases of healthy children were tested;and 595 cases of various kinds of kidney diseases were also included. At the same time, their serum creatinine and creatinine clearance(Ccr) were also measured.Results Cystatin C mean value at birth is typically double that found in adulthood,it decreased to adult level at about 1 year later (1 mg/L),and this level continued to about sixties, then it showed a trend of increase in people older than 60.A significant positive correlation was demonstrated between serum cystatin C and creatinine in various kidney diseases;Logarithm of creatinine clearance showed a significant negative correlation with both logarithm of cystatin C and logarithm of creatinine.when Ccr was abnormal,the accordance rate of cystatin C is higher than that of creatinine.Conclusions Serum cystatin C is more sensitive than creatinine,and is fit for children,old people continuous surveying.