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A commercial PCV2a-based vaccine significantly reduces PCV2b transmission in experimental conditions
Affiliation:1. Departments of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN 55108, United States;2. Departments of Veterinary Population Medicine, University of Minnesota, St. Paul, MN 55108, United States;1. Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain;2. Departament de Ciència Animal i dels Aliments, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain;3. Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico;4. Swine Veterinarians, Valencia, Spain;5. Merial S.A.S., BP 7123, 69348 Lyon, France;6. Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain;1. Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Ave, St. Paul, MN 55108, USA;2. Centers for Epidemiology and Animal Health, USDA-APHIS-VS, 2150 Centre Avenue, Building B, MS 2E7 Fort Collins, CO, USA;1. Department of Animal Medicine, Production and Health (MAPS), University of Padua, Viale dell’Università 16, 35020 Legnaro (PD), Italy;2. Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Barcelona, Spain;3. MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
Abstract:Transmission characteristics of PCV2 have been compared between vaccinated and non-vaccinated pigs in experimental conditions. Twenty-four Specific Pathogen Free (SPF) piglets, vaccinated against PCV2 at 3 weeks of age (PCV2a recombinant CAP protein-based vaccine), were inoculated at 15 days post-vaccination with a PCV2b inoculum (6  105 TCID50), and put in contact with 24 vaccinated SPF piglets during 42 days post-inoculation. Those piglets were shared in six replicates of a contact trial involving 4 inoculated piglets mingled with 4 susceptible SPF piglets. Two replicates of a similar contact trial were made with non-vaccinated pigs. Non vaccinated animals received a placebo at vaccination time and were inoculated the same way and at the same time as the vaccinated group. All the animals were monitored twice weekly using quantitative real-time PCR and ELISA for serology until 42 days post-inoculation. The frequency of infection and the PCV2 genome load in sera of the vaccinated pigs were significantly reduced compared to the non-vaccinated animals. The duration of infectiousness was significantly different between vaccinated and non-vaccinated groups (16.6 days [14.7;18.4] and 26.6 days [22.9;30.4] respectively). The transmission rate was also considerably decreased in vaccinated pigs (β = 0.09 [0.05–0.14] compared to β = 0.19 [0.11–0.32] in non-vaccinated pigs). This led to an estimated reproduction ratio of 1.5 [95% CI 0.8 – 2.2] in vaccinated animals versus 5.1 [95% CI 2.5 – 8.2] in non-vaccinated pigs when merging data of this experiment with previous trials carried out in same conditions.
Keywords:Porcine Circovirus type 2  Vaccination  Transmission  Reproduction number
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