Development and introduction of inactivated poliovirus vaccines derived from Sabin strains in Japan |
| |
| Institution: | 1. Daiichi Sankyo Co. Ltd., Japan;2. Kitasato Institute for Life Sciences, Laboratory of Viral Infection, Japan;1. National Institute for Communicable Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, P.O. Box 5, Changping, Beijing 102206, PR China;2. Gaobeidian Center for Disease Control and Prevention, Gaobeidian, Hebei Province 074000, PR China;1. Department of Health Services Policy and Management, University of South Carolina, 915 Greene Street, Suite 357, Columbia, SC, 29208, USA;2. Sanofi Pasteur India Private Limited, DDA Commercial Centre, Saket, D-2, Fourth Floor, NewDelhi, 110017, India;3. 204, D-96, Munirka, New Delhi, India;4. Sanofi Pasteur 2, Av Pont Pasteur, 69007, Lyon, France |
| |
| Abstract: | During the endgame of global polio eradication, the universal introduction of inactivated poliovirus vaccines is urgently required to reduce the risk of vaccine-associated paralytic poliomyelitis and polio outbreaks due to wild and vaccine-derived polioviruses. In particular, the development of inactivated poliovirus vaccines (IPVs) derived from the attenuated Sabin strains is considered to be a highly favorable option for the production of novel IPV that reduce the risk of facility-acquired transmission of poliovirus to the communities. In Japan, Sabin-derived IPVs (sIPVs) have been developed and introduced for routine immunization in November 2012. They are the first licensed sIPVs in the world. Consequently, trivalent oral poliovirus vaccine was used for polio control in Japan for more than half a century but has now been removed from the list of vaccines licensed for routine immunization. This paper reviews the development, introduction, characterization, and global status of IPV derived from attenuated Sabin strains. |
| |
| Keywords: | Poliovirus Poliovirus vaccine Inactivated poliovirus vaccine Oral poliovirus vaccine Sabin strain Global polio eradication Vaccine-associated paralytic poliomyelitis Vaccine-derived poliovirus |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
