Myeloid derived suppressor cells and autoimmunity |
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Institution: | 1. Recanati/Miller Transplant Institute, Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10129, USA;2. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10129, USA;3. Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen 4032, Hungary |
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Abstract: | Myeloid-derived suppressor cells are a heterogeneous group of immature myeloid cells with immunoregulatory function. When activated and expanded, these cells can suppress T cell functions via cell-to cell interactions as well as soluble mediators. Recent studies investigated the involvement of MDSC in autoimmune diseases. Some papers have described beneficial effect of MDSC during the course of autoimmune diseases, and suggest a potential role as a treatment option, while others failed to detect these effects. Their contributions to autoimmune diseases are not fully understood, and many questions and some controversies remain as to the expansion, activation, and inhibitory functions of MDSC. This review aims to summarize current knowledge of MDSC in autoimmune disorders. |
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Keywords: | Myeloid derived suppressor cells Type 1 diabetes Rheumatoid arthritis SLE Inflammatory bowel disease |
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