Oligonol,a lychee fruit-derived low-molecular form of polyphenol mixture,suppresses inflammatory cytokine production from human monocytes |
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Institution: | 1. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA;2. Department of Pediatrics, College of Medicine, Ulsan University, Republic of Korea;3. Research and Development Division, Amino Up Chemical Co., Ltd, 004-0839 Sapporo, Japan |
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Abstract: | Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecular form of polyphenol mixture, typically catechin-type monomers and oligomers of proanthocyanidins, which are produced by an oligomerization process. Although previous studies reported anti-inflammatory properties of Oligonol, it is unknown whether and how Oligonol suppresses IL-6 and TNF-α production in human monocytes. The results of our study demonstrate that Oligonol (25 μg/ml) decreases the production of IL-6 and TNF-α from human primary monocytes as measured by flow cytometry and ELISA. Such an anti-cytokine effect was likely mediated by the suppression of NF-κB activation without inducing cell death. Our findings raise the possibility of exploring the benefits of Oligonol in controlling inflammatory conditions, especially those associated with monocytes, in humans. |
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Keywords: | Human Cytokines Monocytes Oligonol Polyphenols |
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