Influenza during pregnancy: Incidence,vaccination coverage and attitudes toward vaccination in the French web-based cohort G-GrippeNet |
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| Institution: | 1. Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’épidémiologie et de Santé Publique (IPLESP UMRS 1136), F75012, Paris, France;2. Department of Infectious Diseases, CIC Cochin-Pasteur, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France;3. INSERM CIC 1417, Paris, France;4. INSERM U 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris, France;5. Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France;6. Clinical Investigation Center (CIC) INSERM 1432; Gynecology and Obstetrics CIC Network (GO-CIC) & Hepato-gastroenterology Department, Dijon Hospital, France;7. Department of Obstetrics and Gynecology, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France;2. Facultad de Enfermería y Podología, Universitat de València, Valencia, Spain;1. World Health Organization, Geneva, Switzerland;2. UNICEF Supply Division, Copenhagen, Denmark;3. Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA;4. National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA;1. Department of Family Medicine, Myongji Hospital, Seonam University, College of Medicine, Gyeonggi-do, Republic of Korea;2. Department of Epidemiology and Health Promotion and Institute for Health Promotion, Graduate School of Public Health, Yonsei University, 03722 Seoul, Republic of Korea;3. Department of Internal Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea;4. Department of Family Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea;5. Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul Medical Center, Seoul, Republic of Korea;1. Division of Management, Policy and Community Health, University of Texas School of Public Health, San Antonio, TX, USA;2. Institute for Health, Health Care Policy, and Aging Research, and Department of Economics, Rutgers University, New Brunswick, NJ, USA;3. National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA;4. Medical Research Council: Respiratory and Meningeal Pathogens Research Unit and Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa;5. Department of Preventive Medicine and Community Health, New Jersey Medical School, Rutgers University, Newark, NJ, USA;1. HealthPartners Institute for Education and Research, Minneapolis, MN, United States;2. Yale University School of Medicine, Department of Obstetrics, Gynecology, & Reproductive Sciences, New Haven, CT, United States;3. Kaiser Permanente of Northern California, Oakland, CA, United States;4. Kaiser Permanente of Southern California, Pasadena, CA, United States;5. Kaiser Permanente Northwest, Portland, OR, United States;6. Harvard Pilgrim Health Care Institute & Harvard Medical School, Boston, MA, United States;7. Institute for Health Research, Kaiser Permanente Colorado and Department of Ambulatory Care Services, Denver Health, Denver, CO, United States;8. Group Health Cooperative, Seattle, WA, United States;9. Kaiser Permanente Georgia, Atlanta, GA, United States;10. Centers for Disease Control and Prevention, Atlanta, GA, United States |
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| Abstract: | IntroductionPregnancy is a risk factor for severe influenza. However, data on influenza incidence during pregnancy are scarce. Likewise, no data are available on influenza vaccine coverage in France since national recommendation in 2012. We aimed to assess these points using a novel nationwide web-based surveillance system, G-GrippeNet.MethodsDuring the 2014/2015 influenza season, pregnant women living in metropolitan France were enrolled through a web platform (https://www.grippenet.fr/). Throughout the season, participants were asked to report, on a weekly basis, if they had experienced symptoms of influenza-like-illness (ILI). ILI episodes reported were used to calculate incidence density rates based on period of participation from each participant. Vaccination coverage was estimated after weighing on age and education level from national data on pregnant women. Factors associated with higher vaccination coverage were obtained through a logistic regression with Odds Ratio (OR) corrected with the Zhang and Yu method.ResultsA total of 153 women were enrolled. ILI incidence density rate was 1.8 per 100 person-week (95%CI, 1.5–2.1). This rate was higher in women older than 40 years (RR = 3.0, 95%CI 1.1–8.3], p = 0.03) and during first/second trimesters compared to third trimester (RR = 4.0, 95%CI 1.4–12.0], p = 0.01). Crude vaccination coverage was 39% (95%CI, 31–47) and weighted vaccination coverage was estimated at 26% (95%CI, 20–34). Health care provider recommendation for vaccination (corrected OR = 7.8; 95%CI 3.0–17.1]) and non-smoking status (cOR = 2.1; 95%CI 1.2–6.9]) were associated with higher vaccine uptake.ConclusionThis original web based longitudinal surveillance study design proved feasible in pregnant women population. First results are of interest and underline that public health policies should emphasize the vaccination promotion through health care providers. |
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| Keywords: | Influenza Pregnancy Incidence Vaccination Surveillance Attitudes |
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