Glyceradehyde-3-phosphate dehydrogenase as a suitable vaccine candidate for protection against bacterial and parasitic diseases |
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| Institution: | 1. Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China;2. Liuzhou Municipal Center for Disease Control and Prevention, Liuzhou 545007, Guangxi, China;3. Shenzhen Kangtai Biological Products Co., LTD., Shenzhen 518057, Guangdong, China;4. Guangxi Provincial Centers for Disease Control and Prevention, Nanning 530028, Guangxi, China;1. Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;2. Division of Swine Medicine of the Department for Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;3. Division of Veterinary Epidemiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;1. Epidemiology Unit, Victorian Infectious Disease Reference Laboratory at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia;2. National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia;3. University of Otago, Wellington, New Zealand;1. Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands;2. Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands;1. Norwegian University of Life Sciences, P.O. Box 8146 Dep, N-0033 Oslo, Norway;2. BluGen Korea, 106-14, Songjeongjungang-ro 5 beon-gil, Busan, Republic of Korea;3. Fish Breeding Center, NIFS, Busan, Republic of Korea;4. Biotechnology Research Division, NIFS, Busan, Republic of Korea |
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| Abstract: | The enzyme glyceraldehyde-3-P-dehydrogenase (GAPDH) has been identified as having other properties in addition to its key role in glycolysis. The ability of GAPDH to bind to numerous extracellular matrices, modulation of host-immune responses, a role in virulence and surface location has prompted numerous investigators to postulate that GAPDH may be a good vaccine candidate for protection against numerous pathogens. Although immune responses against GAPDH have been described for many microorganisms, vaccines containing GAPDH have been successfully tested in few cases including those against the trematode—Schistosoma mansoni, the helminth—Enchinococcus multilocularis; the nematode filaria— Litomosoides sigmodontis; fish pathogens such as Aeromonas spp., Vibrio spp., Edwarsiella spp., and Streptococcus iniae; and environmental streptococci, namely, Streptococcus uberis and Streptococcus dysgalactiae. Before GAPDH-based vaccines are considered viable options for protection against numerous pathogens, we need to take into account the homology between the host and pathogen GAPDH proteins to prevent potential autoimmune reactions, thus protective GAPDH epitopes unique to the pathogen protein must be identified. |
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| Keywords: | GAPDH Vaccines Protection |
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