HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia |
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| Institution: | 1. Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia;2. Department of Medicine, Putrajaya Hospital, Wilayah Persekutuan Putrajaya, Malaysia;3. Department of Medicine, Hospital Raja Perempuan Bainun, Ipoh, Perak, Malaysia;4. Department of Medicine, Hospital Selayang, Selangor, Malaysia;5. Department of Medicine, Hospital Tunku Ja’afar Seremban, Negari Sembilan, Malaysia;6. Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Selangor, Malaysia;7. Department of Medicine, Tengku Ampuan Afzan Hospital, Kuantan, Pahang, Malaysia;8. Universiti Kuala Lumpur, Royal College of Medicine Perak, No 3, Jalan Greentown, 30450 Ipoh, Perak, Malaysia;9. Rheumatology Unit, Department of Medicine, CMM L8:O4, Karolinska University Hospital and Karolinska Institutet, 17176 Stockholm, Sweden |
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| Abstract: | A total of 951 Southeast Asia Malays from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, there were significant deviation from Hardy-Weinberg proportions for the HLA-A (p < 0.0001), -B (p < 0.0001), -DRB1 (p < 0.0001) and -DQB1 (p < 0.01) loci. Minor deviations from HWEP were detected for HLA-C (p = 0.01). This genotype data was available in Allele Frequencies Network Database (AFND) Gonzalez-Galarza et al. (2015). |
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| Keywords: | HLA alleles Malays Population Genetic |
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