National hospital data for intussusception: Data linkage and retrospective analysis to assess quality and use in vaccine safety surveillance |
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| Affiliation: | 1. Population, Policy and Practice Programme, University College London, Institute of Child Health, London, England, United Kingdom;2. Paediatric Surgical Unit, Sheffield Children''s NHS Foundation Trust, Sheffield, England, United Kingdom;3. Health Protection Scotland, NHS National Services Scotland, Glasgow, Scotland, United Kingdom;4. British Paediatric Surveillance Unit, Royal College of Paediatrics and Child Health, London, England, United Kingdom;1. Department of Civil Engineering, Iran University of Science and Technology, Narmak, 1684613114, Tehran, Iran;2. Department of Marine and Ecological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965-6565, United States of America;3. School of the Environment, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia;1. Atmospheric Modeling and Analysis Division, USEPA, RTP, NC, USA;2. TNO Department Climate, Air and Sustainability, Utrecht, The Netherlands;3. Air Quality Research Division, Environment Canada, Toronto, Ontario, Canada;1. Department of Pediatrics I, University Children''s Hospital Heidelberg, Heidelberg, Germany;2. Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany;3. Coordination Centre for Clinical Trials, Heidelberg University, Heidelberg, Germany;4. Eurotransplant Foundation, Leiden, the Netherlands;5. Centre for Paediatrics and Adolescent Medicine of Hannover Medical School, Hannover, Germany;6. University Children''s Hospital, Essen, Germany;7. Great Ormond Street Hospital for Children, London, United Kingdom;8. Royal Manchester Children''s Hospital, Manchester, United Kingdom;9. Gazi University, Ankara, Turkey;10. Hacettepe University, Ankara, Turkey;11. First Department of Pediatrics, Semmelweis University, Budapest, Hungary;12. University Children''s Hospital Motol, 2nd Medical Faculty, Charles University, Prague, Czech Republic;13. Radboud UMC, Nijmegen, the Netherlands;14. University Children''s Hospital, Leuven, Belgium;15. Children''s Memorial Health Institute, Warsaw, Poland;1. Cardiology department, les hôpitaux de Chartres, BP 30407, 28018, Chartres, France;2. Cardiology department, clinique Saint-Gatien, 37000 Tours, France;3. Cardiology department, centre hospitalier de Bourges, 18000 Bourges, France;4. Cardiology department, centre hospitalo-universitaire de Tours, 37170 Chambray-lès-Tours, France;5. Cardiology department, clinique Oreliance, 45000 Orléans, France;6. Cardiology department, centre hospitalier régional d’Orléans, Orléans, France;7. Agence régionale de santé (ARS), BP 74409, 45044 Orléans, France;8. Clinique Ambroise-Paré, 92200 Neuilly-sur-Seine, France;9. Unité régionale d’épidémiologie hospitalière (UREH), 37000 Tours, France;10. Université de Tours, faculté de médecine, 37000 Tours, France;1. Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA;2. Lacawac Sanctuary and Biological Field Station, Lake Ariel, PA 18436, USA;3. Hancock Biological Station, Murray State University, Murray, KY 42071, USA |
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| Abstract: | ObjectivesTo assess the quality of national Hospital Episode Statistics (HES) data for intussusception, and evaluate this routinely collected database for rotavirus vaccine safety surveillance by estimating pre-vaccination trends in intussusception hospitalisation.MethodsData linkage was performed between HES and prospective intussusception data from the British Paediatric Surveillance Unit (BPSU), followed by capture–recapture analysis to verify HES data quality. Inclusion criteria were infants aged less than 12 months and admitted for intussusception to National Health Service (NHS) hospitals in England from March 2008 to March 2009. To estimate pre-vaccination incidence rates of intussusception, we performed a retrospective analysis of HES data. Infants aged less than 12 months and admitted for intussusception to NHS hospitals in England between 1995 and 2009 were included.ResultsData linkage between 254 cases of intussusception identified in HES data and 190 cases reported via the BPSU resulted in 163 cases common to both data sources. Of remaining 91 cases in HES, 37 had confirmed intussusception. HES data accuracy was 78.7% (200 confirmed/254 cases) and completeness for intussusception was 86% (163 matched/190 BPSU cases) compared to 81.5% (163 matched/200 HES cases) for BPSU. A total of 233 (95% CI: 227.4 to 238.8) intussusception cases were estimated for the infant population (2008 to 2009). For retrospective analysis, of 6462 intussusception admissions in HES data (1995 to 2009), 1594 (24.7%) were duplicate admissions. A declining trend in intussusception incidence was observed in the infant population, from 86/100,000 in 1997 to 34/100,000 in 2009 (60% reduction, P < 0.001). Cosinor modelling showed an excess of cases among infants in winter and spring (P < 0.001, n = 4957, 1995 to 2009).ConclusionNational hospital data capture the majority of admissions for intussusception and should be considered for the post-implementation surveillance of rotavirus vaccine safety in England. |
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| Keywords: | Vaccine safety Intussusception Incidence trend Hospital data Surveillance HES" },{" #name" :" keyword" ," $" :{" id" :" kw0035" }," $$" :[{" #name" :" text" ," _" :" Hospital Episode Statistics BPSU" },{" #name" :" keyword" ," $" :{" id" :" kw0045" }," $$" :[{" #name" :" text" ," _" :" British Paediatric Surveillance Unit NHS" },{" #name" :" keyword" ," $" :{" id" :" kw0055" }," $$" :[{" #name" :" text" ," _" :" National Health Service ONS" },{" #name" :" keyword" ," $" :{" id" :" kw0065" }," $$" :[{" #name" :" text" ," _" :" Office for National Statistics ICD-10" },{" #name" :" keyword" ," $" :{" id" :" kw0075" }," $$" :[{" #name" :" text" ," _" :" International Classification of Diseases 10th revision |
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