| CagA对幽门螺杆菌与宿主细胞相互作用影响的研究进展 |
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| 引用本文： | 姬晓云,张建中. CagA对幽门螺杆菌与宿主细胞相互作用影响的研究进展[J]. 中国全科医学, 2007, 10(12): 1033-1035 |
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| 作者姓名： | 姬晓云 张建中 |
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| 作者单位： | 102206北京市,中国疾病预防控制中心传染病预防控制所 |
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| 摘 要： | 在体外实验中,幽门螺杆菌(Helicobacter pylori,H.pylori)和宿主细胞相互作用后发生很多变化,而H.pylori细胞毒素相关蛋白(cytotoxin associated gene A,CagA)是H.pylori重要的毒力因子之一,在H.pylori与宿主细胞相互作用中起着非常重要的作用,包括CagA转运进入细胞、CagA磷酸化和断裂,以及引起胞内信号转导通路的改变.本文就CagA对H.pylori与宿主细胞的相互作用影响进行综述.
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| 关 键 词： | 螺杆菌,幽门 信号传导 |
| 文章编号： | 1007-9572(2007)12-1033-03 |
| 修稿时间： | 2007-04-11 |
Advance of CagA''''s Influences on the Interaction of Helicobacter Pylori and Host Cell |
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| JI Xiao-yun,ZHANG Jian-zhong. Advance of CagA''''s Influences on the Interaction of Helicobacter Pylori and Host Cell[J]. Chinese General Practice, 2007, 10(12): 1033-1035 |
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| Authors: | JI Xiao-yun ZHANG Jian-zhong |
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| Abstract: | In vitro,CagA plays an important role in the interaction between H pylori and host cells,including the translocation of CagA into host cells,the phosphorylation and breakage of CagA,and changes of the intracellular signal transduction pathways.This article gives a brief review on the function of CagA in the interaction between H.pylori and host cells. |
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| Keywords: | CagA |
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