食管鳞状上皮和鳞癌的凝集标记研究

应用免疫组织化学ＡＢＣ技术对８２例人食管鳞状上皮和鳞癌标本进行６种凝集素标记观察。结果表明，食管非癌上皮和鳞癌中６种凝集素的分布和含量有明显差异，非癌上皮的凝集素受体主要分布在胞膜上，而从异型增生开始到高分化鳞癌至低分化鳞癌，所结合的凝集素受体的分布逐渐从胞膜移至胞浆和核膜上，凝集素结合的阳性率随细胞分化水平的降低而逐渐升高，表明慢性炎性增生和不典型增生是食管粘膜癌变的基础。

Study on the Squamous Epithelium and Squamous Cell Carcinoma of Human Esophageal Mucosa by Lectin Binding

Six lectins were observed on specimens of 82 cases of the squamous epithelium and squamous cell carcinoma of human esophageal mucosa by means of immunohistochemical ABC technique. The results showed that the amounts and distribution of 6 lectins revealed significant difference between non-cancerous epithelium and squamous cell carcinoma of esophagus. Lectin receptors of non-cancerous epithelium were mainly located of the cytoplasmic memberane. Progressing from atypical hyperplasia to well-differentiated squamous carcinoma, then to poorly-differentiated squamous carcinoma, the distribution of labeling lectin-receptors gradually moved from the cytoplasmic memberane to the cytoplasm and the nucleus memberane of tumors cell. The positive rate of lectin-labeling was found to be gradually raised with the drop of level of cell differentiation. From these results,it suggests that chronic inflammatory hyperplasia and dysplasia are fundamental phases of carcinomatous change in the esophageal mucosa.