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OSAHS患者血清瘦素水平测定及其临床意义
引用本文:陆晓玲,钦光跃,杜坚宗,黄勍栋,吴健,顾亮,吴金彦,赵恬,唐婷玉. OSAHS患者血清瘦素水平测定及其临床意义[J]. 浙江医学, 2008, 30(8)
作者姓名:陆晓玲  钦光跃  杜坚宗  黄勍栋  吴健  顾亮  吴金彦  赵恬  唐婷玉
作者单位:浙江医院呼吸内科,杭州,310013
摘    要:目的 探讨测定阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清瘦素水平的临床意义.方法 选择年龄、性别差异无统计学意义的肥胖OSAHS患者65例(肥胖OSAHS组)、非肥胖OSAHS患者39例(非肥胖OSAHS组)、单纯肥胖患者13例(肥胖对照组)和健康人22名(正常对照组)进行多导睡眠图(PSG)监测,用放射免疫法测定所有对象的血清瘦素水平.结果 肥胖OSAHS组血清瘦素水平(17.85±7.86)ng/L较非肥胖OSAHS组(13.42±6.11)ng/L增高(P<0.01);肥胖OSAHS及非肥胖OSAHS组血清瘦素较肥胖对照组(12.25±4.72)ng/L、正常对照组(7.86±2.02)ng/L增高(P<0.05或0.01).OSAHS患者血清瘦素水平较对照组升高(F=7.01,P<0.01),肥胖患者血清瘦素水平较非肥胖者升高(F=17.38,P<0.01),肥胖与OSAHS无交互作用(F=1.44,P>0.05).血清瘦素水平与体重指数(BMI)、微觉醒指数(MAI)、呼吸暂停低通气指数(AHI)、氧减指数(ODI4)呈正相关(r=0.39、0.17、0.24、0.24,P<0.01或0.05). 结论 OSAHS患者、肥胖患者血清瘦素水平增高,除肥胖因素外,OSAHS本身也是引起瘦素水平升高的原因.

关 键 词:阻塞性睡眠呼吸暂停低通气综合征  瘦素  肥胖

Serum leptin levels in patients with obstructive sleep apnea/hypopnea syndrome
LU Xiaoling,QIN Guangyue,DU Jianzong,et al.. Serum leptin levels in patients with obstructive sleep apnea/hypopnea syndrome[J]. Zhejiang Medical Journal, 2008, 30(8)
Authors:LU Xiaoling  QIN Guangyue  DU Jianzong  et al.
Affiliation:LU Xiaoling,QIN Guangyue,DU Jianzong,et al.Department of Respiratory Medicine,Zhejiang Hospital,Hangzhou 310013,China
Abstract:Objective To investigate serum leptin levels in patients with obstructive sleep apnea/hypopnea syndrome(OSAHS).Methods Polysomnography(PSG) was performed in 65 obese OSAHS patients,39 non-obese OSAHS patients,13 obese subjects and 22 normal healthy adults.Serum leptin levels were measured by radioimmunoassay.Results Serum leptin levels were significant higher in obese OSAHS patients than those in non-obese OSAHS patients(P<0.01);Serum leptin levels were significant higher in OSAHS patients than those in obe...
Keywords:Obstructive sleep apnea /hypopnea sydrome Leptin Obesity  
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