A case of acute vascular rejection after overseas deceased kidney transplantation |
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| Authors: | Tomokazu Shimizu Hideki Ishida Hiroshi Kobayashi Kazunari Tanabe Kentaro Masumoto Kuniko Tsunoyama Junpei Iizuka Tadahiko Tokumoto Shun'ichi Kajimoto Yutaka Yamaguchi |
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| Affiliation: | Department of Urology, Tokyo Women's Medical University, Tokyo, Japan;, Department of Urology, Toda Central Medical Hospital, Saitama, Japan;, Department of Urology, Tsudanuma Hospital, Chiba, Japan;, Department of Pathology, Kashiwa Hospital, The Jikei University School of Medicine, Chiba, Japan |
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| Abstract: | Abstract: A 54-yr-old Japanese male received overseas deceased kidney transplantation in January 2006. His allograft functioned immediately and he received immunosuppression with cyclosporine A (CyA), mycophenolate mofetil (MMF), and prednisone (PR). On day 24 after transplantation, he came back to Japan. His serum creatinine level (s-Cr) was 1.39 mg/dL at two months after transplantation when he was admitted into Toda Central General Hospital on March 2006, for follow-up his renal allograft. He had taken only two immunosuppressive drugs, MMF and PR, and had not taken CyA at that time. His serum creatinine gradually rose after hospitalization. Allograft biopsy performed on April 6, 2006, showed acute vascular rejection (Banff 97 acute/active cellular rejection Grade III), together with suspicious for acute humoral rejection (Banff 97 antibody-mediated rejection Grade II). After treatment of two courses of steroid pulses and five d of gusperimus, acute vascular rejection and acute humoral rejection were relieved, which had been proven by the third allograft biopsy. In conclusion, this was a case of acute vascular rejection after overseas deceased kidney transplantation, resulted from non-compliance with immunosuppressive therapy. |
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| Keywords: | acute vascular rejection non-compliance overseas deceased kidney transplantation |
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