肾炎2号防治IgA肾病大鼠的实验研究

目的]观察肾炎2号对IgA肾病大鼠的防治作用,并探讨其作用机理。方法]使用口服和尾静脉注射牛血清白蛋白(BSA)的方法制作大鼠IgA肾病模型,治疗组、对照组造模同时分别给予肾炎2号(15g/kg)和福辛普利(4.17mg/kg)至12周末。观察尿常规、24h尿蛋白定量、血常规、肝肾功能的变化及肾组织的病理改变。结果]1.各组大鼠尿常规均未见红细胞。2.治疗组、对照组第7～12周末24h尿蛋白定量较模型组明显降低(P<0.01),但治疗组与对照组比较无显著的差别(P>0.05)。3.各组血常规和肝肾功能相比无明显统计学差异(P>0.05)。4.与模型组比较,治疗组大鼠肾组织系膜区IgA沉积减少;系膜基质、系膜细胞增生程度减轻,但治疗组、对照组相比无明显统计学差异(P>0.05)。结论]肾炎2号具有降低蛋白尿、抑制系膜区IgA沉积、减少系膜基质和系膜细胞增生的作用,与西药福辛普利相比无明显差异。

Experimental Research on Nephritis Ⅱ Preventing and Treating IgA Nephritic Rats

Objective] To observe Nephritis II preventing and treating IgA nephritic rats,and explore its functional mechanism.Method] Make IgA nephritic model with orally taking and tail vein injected with BSA;meanwhile respectively give the treatment and control groups Nephritis II(15g/kg)and Fuxinpuli(4.17 mg/kg)till the end of 12 weeks.Observe pathological changes of urine,24-h urinary protein,blood test,liver and kidney function and kidney tissue.Result] 1.There're no red cells in urine exam for all groups.2.At...