| 2型糖尿病患者血管内皮功能的改变 |
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| 引用本文： | 郑仁东,任安,陈若平,肖淳纯,陈燕.2型糖尿病患者血管内皮功能的改变[J].中国临床保健杂志,2009,12(2):134-135. |
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| 作者姓名： | 郑仁东 任安 陈若平 肖淳纯 陈燕 |
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| 作者单位： | 安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥,230001 |
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| 摘 要： | 目的观察2型糖尿病患者血管内皮功能的改变。方法临床随机选择40例2型糖尿病患者为糖尿病组和32例正常体检者作为健康对照组。测定血管内皮指标:血清内皮素-1(ET-1)水平、一氧化氮(NO)水平、总一氧化氮合酶(T-NOS)和诱导型一氧化氮合酶(iNOS)的活力水平。并同时测定空腹血糖、餐后2 h血糖、糖化血红蛋白、腰臀比、体质量指数、血压。结果糖尿病组ET-1高于健康对照组,而NO、T-NOS、iNOS低于健康对照组,其差异具有统计学意义(P<0.05)。单因素相关分析发现,血清ET-1与HbA1c呈显著正相关,而NO与HbA1c负相关。ET-1与NO水平显著负相关。结论内皮素-1、一氧化氮及一氧化氮合酶(NOS)参与了2型糖尿病血管病变。
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| 关 键 词： | 糖尿病 2型 内皮 缩血管肽1 一氧化氮 |
Clinical research of vascular endothelial function change in type 2 diabetes patients |
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| ZHENG Ren-dong,REN An,CHEN Ruo-ping,XIAO Chun-chun,CHEN Yan.Clinical research of vascular endothelial function change in type 2 diabetes patients[J].Chinese JOurnal of Clinical Healthcare,2009,12(2):134-135. |
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| Authors: | ZHENG Ren-dong REN An CHEN Ruo-ping XIAO Chun-chun CHEN Yan |
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| Institution: | Department of Endocrinology;Anhui Provincial Hospital;Hefei 230001;China |
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| Abstract: | Objective To observe the vascular endothelial function in patients with type 2 diabetes.Methods 40 patients of type 2 diabetes were randomly selected into treatment group,with 32 normal subjects into control group.Test vascular endothelial indicators,with the levels of endothelin-1(ET-1),nitric oxide(NO),total nitric oxide synthase(T-NOS) and induce nitric oxide synthase(iNOS) included.Additionally,fasting plasma glucose,2 hours postprandial plasma glucose,HbA1c,waist-to-hip ratio,body mass index,blood pres... |
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| Keywords: | Diabetes mellitus type 2 Endothelin-1 Nitric oxide |
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