布地奈德及孟鲁斯特治疗小儿咳嗽变异性哮喘的疗效观察

目的：观察布地奈德与孟鲁斯特治疗小儿咳嗽变异性哮喘的疗效与差异。方法研究纳入2013年1月~2014年1月入院治疗咳嗽变异性哮喘共102例患儿，按照治疗方法分为两组，51例患儿使用布地奈德治疗2周，51例患儿使用孟鲁斯特治疗2周，两组患者气喘发作时同时给予雾化沙丁胺醇缓解，观察两组患儿2周后咳嗽症状缓解率、肺功能指标（FEV1、FEV1/FVC、PEF）和不良反应。结果孟鲁斯特组症状缓解率为88.2%（45/51）,布地奈德组为86.2%（44/51），两组缓解率相似（P＞0.05）；孟鲁斯特组1周缓解显效率为52.9%（27/51），布地奈德组为47.1%（24/51），孟鲁斯特组较高（P＜0.05）。两组患者治疗后FEV1、FEV1/FVC和PEF指标较治疗前均明显改善（P＜0.05）；布地奈德组和孟鲁斯特组治疗后FEV1、FEV1/FVC和PEF指标变化结果相似（P＞0.05）。结论布地奈德与孟鲁斯特在控制小儿咳嗽变异性哮喘的症状缓解、肺功能指标均相似，但孟鲁斯特在治疗第1周的症状缓解显效率较高。

The clinical observation of budesonide and montelukast in treatment of children cough variant asthma

Objective To observe the effect and difficult of Budesonide and Montelukast in treatment of children cough variant asthma.Methods 102 patients with children cough variant asthma in our hospital from January 2013 to January 2014 were divided into two groups based on treatment ways.51 patients used Budesonide with two weeks treatment,51 patients used Montelukast with two weeks treatment,patients of two group were used Salbutamol when asthma attack, the cough response rate,lung function indices（FEV1、FEV1/FVC,PEF） and adverse reaction were observed after two weeks.Resultsthe cough response rate of Budesonide group was 88.2%（45/51）,the cough response rate of Montelukast group was 86.2%（44/51）,there was no different of two groups（P〉0.05）;the cough response rate of Budesonide group after 1 week was 52.9%（27/51）,the cough response rate of Montelukast group after 1 week was 47.1%（24/51）,cough response rate of Montelukast group was better than Budesonide group（P〈0.05）.the lung function indices such as FEV1、FEV1/FVC and PEF of two groups after treat were better than before（P〈0.05）,there was no different about lung function indices such as FEV1、FEV1/FVC and PEF of two groups（P〉0.05）. Conclusionthere has no different about cough response rate and lung function indices of two groups after two weeks,but he cough response rate of Montelukast group after 1 week is better than Budesonide group.