新生儿重度高胆红素血症166例相关因素分析

目的：观察新生儿重度高胆红素血症的发病原因和临床特点，对治疗方案和预防措施提供针对性的帮助和改善。方法回顾性分析我院新生儿科2012年1月~2013年9月收治住院的166例重度高胆红素血症患儿的临床资料。结果我院2012年1月~2013年9月共收治新生儿高胆红素血症患儿1256例，其中重度高胆红素血症患儿166例，占13.2%；溶血因素、感染因素和围产因素与检测指标呈正相关（P＜0.05），且逐步回归分析表明发现溶血因素是新生儿重度高胆红素血症发病的主要危险因素（P＜0.05）；积极有效的干预治疗，可以控制患儿病情，提高患者治愈率。结论早期新生儿是重度高胆红素血症的高发人群，造成新生儿重度高胆红素血症的原因复杂，其中溶血因素比例最高，感染和围产因素次之。所以应该对早期新生儿重点观察，发现症状需要及时果断干预，以减少其发展成高胆红素血症的可能性。

Correlation analysis of 166 cases of neonatal severe hyperbilirubinemia

Objective To discuss the causes and clinical features of neonatal severe hyperbilirubinemia, and to provide the specific therapeutic schedule and precaution. Methods Study the clinical date of 116 cases of neonatal severe hyperbilirubinemia, who received the treatment from Jan.2012 to Sept.2013 in our hospital＆#39;s neonatology retrospectively. Results Among all the 1256 cases, there were total 166 severe hyperbilirubinemia patients （13.2%）. There was a positive relationship between hemolysis, infection, perinatal factors and detection index（P 〈 0.05）, and logistic regression analysis showed that Hemolysis factor was the main dangerous factor of neonatal severe hyperbilirubinemia（P 〈 0.05）. Effective intervention and treatment were helpful for controlling and treating the disease. Conclusion Early newborn are at high risk of neonatal severe hyperbilirubinemia. The causes of neonatal severe hyperbilirubinemia are complicated,and among all hemolysis factor is the main one,infection and perinatal factors are following. Doctors should put emphasis on early newborn, and provide immediate intervention to avoid any possibility of severe hyperbilirubinemia.