牙周基础治疗对2型糖尿病相关性牙周炎患者血糖控制的Meta分析

目的系统评价牙周基础治疗对2型糖尿病相关性牙周炎患者血糖控制的影响，探讨牙周基础治疗在糖尿病治疗中的具体作用。方法计算机检索Cochrane图书馆对照试验注册中心、Medline、EMbase、SIGLE、GreyNet、NTIS、中国生物医学文献数据库、中文科技期刊全文数据库、中国期刊全文数据库和万方数据库，查找有关牙周基础治疗对糖尿病血糖控制影响的研究。检索时限均为1991-2011年4月31日。均由2名评价者独立选择试验、提取资料和评估方法学质量，然后采用RevMan 5．1软件对资料进行Meta分析。纳入7个研究，共计471例受试患者。结果牙周基础治疗能明显降低2型糖尿病相关性牙周炎患者糖化血红蛋白的水平，组间差异有统计学意义（95％CI：-0．94—0．22，P=0．001）。治疗组牙周袋探诊深度低于对照组，组间差异也有统计学意义（95％CI：-2．26～0．69，P=0．0002）。结论牙周基础治疗有利于2型糖尿病相关性牙周炎患者总体血糖水平的控制。

Meta-analysis of periodontal treatment on glycaemic control of type 2 diabetic associated periodontitis patients

Objective To evaluate the effect of periodontal therapy on glycaemic control in type 2 diabetic associated periodontitis patients, and explore the role of periodontal therapy in the treatment of diabetes. Methods Studies of periodontal therapy on glycaemic control in diabetic patients were searched in Cochrane Central Register of Controlled Trials （Central）, Medline, EMbase, SIGLE, GreyNet, NTIS, CBMdisc, VIP, CNKI and Wanfang data from 1991＇ to April 31, 2011. The studies＇ selection, extraction and evaluation were performed by two reviewers independently, and meta-analysis was performed with RevMan 5.1 software. A total of 7 studies involving 471 partie/pants were included in the review. Results Periodontal treatment could lead to a significant reduction in glycosylated hemoglobin level. The difference between the groups was significant（95%Ch -0.94 to-0.22, P= 0.001）. And the periodontal probing depth in the treatment group was lower than those of the control group, the difference between the groups was also statistically significant（95%CI： -2,26 to -0.69, P=0.000 2）. Conclusion Perio- dontal treatment could improve glycaemic control in type 2 diabetic associated periodontitis patients.