急性脑梗死患者血浆PAI、D-二聚体、TM与痰证、血瘀证的线性回归分析

目的探讨急性脑梗死患者血浆纤溶酶原激活物抑制物(PAI)、D-二聚体、血栓调节蛋白(TM)变化与中医痰证、血瘀证变化的关系。方法观察122例急性脑梗死患者,于入院第1天及第14天测定患者血浆PAI、D-二聚体、TM的含量,并记录中医痰证、血瘀证积分,对化验指标的前后差值及证候积分的前后差值进行线性回归分析。结果PAI变化与痰证积分变化存在线性回归关系(P=0.011),D-二聚体变化与血瘀证积分变化存在线性回归关系(P=0.038),TM变化与血瘀证积分变化存在线性回归关系(P=0.034)。结论PAI、D-二聚体、TM与痰证、血瘀证有相关性,中医痰证、血瘀证的证候变化能在一定程度上体现急性脑梗死患者体内凝血-纤溶失衡时凝血纤溶功能的动态变化。

Linear-regression analysis on serum PAI,D-dimer,TM,phlegm syndrome and blood-stasis syndrome in patients with acute cerebral infarction

Objective To investigate the changes of serum plasminogen activator inhibitor(PAI),D-dimer and thrombomodulin(TM),and the relationship between these changes and phlegm syndrome or blood-stasis syndrome in patients with acute cerebral infarction.Method The patients(n=122) with acute cerebral infarction were observed.On the first and 14th day after the patients hospitalized the serum contents of PAI,D-dimer and TM were determined,the scores of phlegm syndrome and blood-stasis syndrome were recorded,and the linear-regression analysis was carried out on the difference of test indexes and syndrome scores respectively.Result There was a linear-regression relationship between PAI changes and score changes of phlegm syndrome(P=0.011),the same between D-dimer and blood-stasis syndrome(P=0.038),and between TM and blood-stasis syndrome(P=0.034).Conclusion There is a correlation among PAI,D-dimer,TM,phlegm syndrome or blood-stasis syndrome.The symptoms of phlegm syndrome or blood-stasis syndrome can reflect the dynamic changes of blood-clotting function to some extent after the disorder of blood-clotting-fibrinolysis in the patients with acute cerebral infarction.