p53和p21基因蛋白表达与胃癌侵袭力的关系

采用免疫组织化学方法研究了６８例胃癌中癌细胞ｐ５３和ｐ２１基因蛋白表达与癌细胞侵袭力的关系。结果表明：６８例胃癌中有３６例ｐ５３基因蛋白染色阳性（５２．９％），４８例ｐ２１基因蛋白染色阳性（７０．６％）；浸润于浆膜层和肌层的癌细胞ｐ５３蛋白染色的阳性程度明显高于粘膜层癌细胞（Ｐ＜０．０５）；浸润性生长的癌细胞中ｐ５３和ｐ２１蛋白阳性程度均明显强于膨胀性生长的癌细胞（Ｐ＜０．０５）；淋巴结转移病例的癌细胞其ｐ５３和ｐ２１蛋白染色阳性率（分别为５４．３％和７３．９％）与无淋巴结转移的病例（分别为５０．０％和６３．６％）无显著性差异（Ｐ＞０．０５）；有淋巴结转移的病例中，原发癌ｐ５３蛋白阳性强度与转移癌正相关（γ＝０．６８，Ｐ＜０．０１）。结果提示：ｐ５３和ｐ２１基因蛋白染色阳性程度较高的胃癌细胞具有较强的侵袭力。

Relationship Between the Expression of p53 and p21 Proteins andAggression of Gastric Cancer

In order to investigate the relationship between p53 and p21 expression and aggression of gastric carcinoma,68 cases of gastric carcinoma were studied.The results showed that the positive staining of p53 protein was found by immunohistochemical methods in 36 cases(52.9%) and p21 protein positive staining was observed in 48 cases(70.6%) with gastric carcinoma.There was significant difference in degrees of p53 expression among the cancer cells infiltrated in mucosa,muscular and serosa lamina.The strongest p53 and p21 positive staining were found on the cancer cells infiltrating in serosa,while relatively weaker staining showed on the cells in mucosa(P<0.05).Compared with that in the expending grouth cell,the significantly stronger p53 and p21 staining also showed in the cells with infiltrating growth(P<0.05).In the cases with or without lymphatic metastasis the positive rates of p53 and p21 expression were similar(P>0.05).A positive relation of p53 staining was found between the metastasis cancer cellsand the primary cancer cells(r=0.68,P<0.01).The results suggest that the stronger p53 and p21 staining of gastric cancer,the more invasive they are.