晚期胰腺癌的持续腹腔动脉插管化疗

为了观察和评价晚期胰腺癌持续腹腔动脉插管化疗效果，对７例晚期胰腺癌患者行腹腔动脉插管并留置，６例采用ＴＨＰＡＤＭ＋ＨＣＰＴ＋ＣＦ／５Ｆｕ方案，另１例采用Ｇｅｍｃｉｔａｂｉｎｅ＋ＣＦ／５Ｆｕ方案，持续滴注４ｄ。结果完全缓解１例，部分缓解３例，无变化２例，进展１例，有效率为５７．１％（４／７），临床受益疗效７１．４％（５／７）。２例已死亡，５例生存，中位生存期５个月。结果表明持续腹腔动脉插管化疗对晚期胰腺癌有较好疗效，值得临床进一步观察研究。

Continuous Coeliac Arterial Infusion Polychemotherapy for Advanced Pancreatic Cancer

To observe and evaluate the efficiency of continuous coeliac arterial infusion polychemotherapy on advanced pancreatic cancer.4 day long continuous coeliac arterial infusion polychemotherapy was performed in 7 patients with advanced pancreatic cancer,the regimen of pirarubicin,hydroxycamptothecine,calcium folinate and fluorouracil was used in 6 cases and gemcitabine,calcium folinate and fluorouracil in 1.Short term efficiency:complete remission (CR) occured in 1 cases,partial remission(PR) in3,no change(NC) in 2 and progression disease(PD) in 1.The overall response rate (RR) was 57% (4/7).Clinical benefit response(CBR) was 71%(5/7).The median survival time was 5 months.5 patients survived and 2 patients died.Continuous coeliac arterial infusion polychemotherapy is more effective to advanced pancreatic cancer and worth further study.