Neurological aspects of multiple myeloma and related disorders |
| |
Authors: | Dispenzieri Angela Kyle Robert A |
| |
Affiliation: | Mayo Clinic, Medicine, Rochester, Minnesota MN 55905, USA. dispenzieri.angela@mayo.edu |
| |
Abstract: | The spectrum of neurologic complications of multiple myeloma (MM) and related conditions is as diverse as the conditions themselves. Complications range from direct compression (radiculopathy, spinal cord compression, base-of-the-skull tumor) to the infiltrative (amyloid, peripheral neuropathies, and numb chin syndrome of myeloma), the metabolic (slowed mentation from hyperviscosity, hypercalcemia, or uremia), and to autoimmune or cytokine-mediated (peripheral neuropathy). The two most common presentations are the compressive radiculopathy one sees in multiple myeloma and the peripheral neuropathies associated with many of the other disorders. The authors will review the neurologic complications of MM, monoclonal gammopathy of undetermined significance (MGUS), Waldenstr?m macroglobulinemia (WM), POEMS syndrome, amyloidosis, and cryoglobulinemia. |
| |
Keywords: | neurologic complications peripheral neuropathy multiple myeloma Waldenströ m macroglobulinemia cryoglobulinemia amyloidosis POEMS syndrome MGUS |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|