Methodology for pharmacokinetic/pharmacodynamic data analysis |
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| Affiliation: | 1. African Institute of Public Health, Ouagadougou, Burkina Faso;2. Directorate of Family Health, Ministry of Health, Ouagadougou, Burkina Faso;3. Fada N’Gourma Regional Hospital, Fada N’Gourma, Burkina Faso;4. Institute for Health and Development, Dakar, Senegal;5. Research Institute of Health Sciences, Ouagadougou, Burkina Faso |
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| Abstract: | This review will highlight the role of exploratory data analysis and nonlinear regression software in pharmacokinetic–pharmacodynamic (PK/PD) data analysis. Kinetic and dynamic modelling situations typical to the pharmacokineticist in the drug industry will be addressed, and two case studies, including single-dose intravenous bolus plasma data and multiple-dose response-time data will be analysed. Approaches to assessing the suitability of model fit to the observed data will be discussed, and a summary of the key features of available commercial PK software will be given. Specific emphasis will be placed on the application of WinNonlin. |
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