虫草活血胶囊治疗难治性肾病综合征临床观察

目的观察虫草活血胶囊治疗难治性肾病综合征的临床疗效。方法将100例难治性肾病综合征患者随机分为治疗组和对照组,各50例,2组均采用泼尼松、环磷酰胺等常规治疗,治疗组加服虫草活血胶囊,每次5粒,每日3次口服。2组均治疗6个月,随访6个月,观察治疗前后24h尿蛋白定量、血浆白蛋白及血脂指标变化。结果治疗组总有效率92%,对照组总有效率74%,2组比较差异有统计学意义（P〈0.05） 治疗组6个月复发率为12%,对照组6个月复发率为30%,2组比较差异有统计学意义（P〈0.05） 2组治疗前后血脂、血浆白蛋白、24h尿蛋白定量比较差异均有统计学意义（P〈0.05）,且2组治疗后比较差异均有统计学意义（P〈0.05）。结论虫草活血胶囊不仅能提高机体免疫力,还能升高血浆白蛋白,降低24h尿蛋白定量,纠正脂质代谢紊乱状态,对降低近期复发率也有一定作用。

Effect of Qidanyishenjingtang pill on diabetic nephropathy

Objective To observe the effect of Qidanyishenjingtang pill on diabetic nephropathy. Methods 210 patients with diabetic nephropathy （DN） were randomly divided into two groups. Patients in control group （n = 100） were treated by routine therapy. Patients in treatment group （ n = 110） were treated by combination of Qida- nyishenjingtang pill and routine therapy. The changes of FPG,2 hPG, HblAc, 24 h urine protein, UAER, BUN, se- rum creatinine （Scr） , TC, TG, LDL - C, and HDL - C were observed before and after treatment. Results The to- tal effective rate in treatment group （ 82.73% ） was higher than that in control group（77.00% , P 〈0.05）. There were significant difference between two groups on FPG, 2hPG, HbAlc, 24 h urine protein, UAER, BUN, and Ser, after treatment （ P 〈 0.05 ）. There were significant difference between before and after treatment on TC, TG, HDL - L LDL - L in two groups （ P 〈 0.05 ）. Improvement of indexes in treatment group were superior to those in control group （ P 〈 0.05 ）. Conclusion Qidanyishenjingtang pill can decrease FPG in patient with DN, relief albuminuria and improve lipid metabolism.