Association of cyclin D1 G870A polymorphism with uterine leiomyoma in women whose body mass index values are above 25 kg/m2

BACKGROUND: Many studies have shown that a polymorphism (G870A) in cyclinD1 (CCND1) is associated with carcinogenesis in a variety ofcancers. Our aim was to determine if an association exists betweenthe CCND1 G870A polymorphism and uterine leiomyoma in Koreanwomen. METHODS: Blood samples of 331 cases and 204 controls aged 47.4 ±7.6 and 46.8 ± 10.4 years (mean ± SD), respectively,were collected. CCND1 genotyping was determined by PCR and restrictionfragment length polymorphism. RESULTS: Allelic frequencies of cases (A, 0.53; G, 0.47) were not significantlydifferent from those of controls (A, 0.49; G, 0.51) (P = 0.22).After adjustment for menarche age and BMI, multivariate logisticregression analysis showed that the AA genotype was not associatedwith increased risk for uterine leiomyoma odds ratio (OR) =1.38, 95% confidence interval (CI); 0.85–2.26, P = 0.19].However, in stratification analysis of cases and controls withBMI >25 kg/m², allelic frequencies of cases (A, 0.56; G,0.44) were significantly different from controls (A, 0.36; G,0.64) (P = 0.005), and the AA genotype was associated with increasedrisk for uterine leiomyoma (OR = 3.61, 95% CI; 1.02–12.73,P = 0.046). Furthermore, the OR for AA compared with combinedGG and AG genotypes was 3.16 (95% CI 1.01–9.92, P = 0.048). CONCLUSIONS: The A allele and AA genotype of CCND1 G870A polymorphism havea significant association with an increased risk of the uterineleiomyoma in obese Korean women.