药物成瘾患者创伤后应激障碍、抑郁、焦虑症状的调查

目的:调查了解药物成瘾者的创伤后应激障碍(PTSD)及焦虑抑郁的共病症状,为寻找更有效的治疗提供理论基础。方法:采用自编问卷、DSM-IV、初级PTSD筛查量表(PC-PTSD)、医院焦虑与抑郁量表(HADS)对年龄和性别相匹配的100例药物成瘾者和98例无任何物质成瘾史的被试测量成瘾状况,PTSD情况以及焦虑抑郁状况,并采用t检验和χ2检验比较成瘾组和对照组在抑郁、焦虑和PTSD得分的差异。结果:成瘾组和对照组在焦虑、抑郁(t=7.17,P<0.001;t=3.01,P<0.01)和PTSD量表(t=-3.39,P<0.001)的得分差异有统计学意义。成瘾组中有抑郁(P<0.01)和焦虑(P<0.01)的人数显著多于对照组;17例(17%)呈现PTSD阳性症状,同时还伴有抑郁、焦虑状况,对照组则有10%的人呈PTSD阳性症状并同时伴有抑郁、焦虑,两组差异没有统计学意义P>0.05)。结论:物质成瘾者PTSD症状及抑郁、焦虑共病症状较为严重,提示对药物成瘾需采用多元治疗方法,对多种不同症状同时进行治疗,才可能有好的治疗效果。

INVESTIGATION ON THE SYMPTOMS OF COMORBIDITY OF DRUG DEPENDENCE,PTSD,DEPRESSION AND ANXIETY

Objective:To investigate the symptoms of comorbidity of drug dependence and post traumatic stress disorder(PTSD),anxiety,depression among drug dependent individuals in compulsory rehabilitation centers.Methods:DSM-IV,PC-PTSD,HADS were adopted to measure the condition of drug use,PTSD,anxiety and depression of 100 drug dependent individuals and 98 samples without drug use history who matched with drug dependent group in age and gender.T-test and χ2 were used to analyze the difference of PTSD,anxiety and depression scores between drug dependent group and the control.Results:Significant difference was found in the mean scores of depression(t=7.17,P<0.001),anxiety(t=3.01,P<0.01) and PTSD(t=-3.39,P<0.001)between the two groups.17% of drug dependent,10% of the control showed PTSD symptoms with depression and anxiety at the same time,no significant difference was found between the two groups(P>0.05).But much more drug dependent individuals showed positive depression(P<0.01) and anxiety symptoms(P<0.01) than the control.Conclusion:The results indicated that a lot of drug dependent individuals have comorbidity symptoms with PTSD,depression or anxiety,which reminds people that comprehensive treatments are needed for different symptoms of drug dependence simultaneously,then the efficacy of the treatment might be improved.