复方苍耳子滴鼻剂对豚鼠变应性鼻炎的影响

目的观察复方苍耳子滴鼻剂对变应性鼻炎模型豚鼠症状的变化和血清组胺含量的影响。方法以甲苯-2,4-二异氰酸甲苯酯(TDI)作为致敏因子建立豚鼠鼻黏膜变态反应模型,以模型组、阳性药物组与空白组为对照,测定各组豚鼠鼻黏膜内组胺的含量及形态组织学的改变。结果 ①鼻部症状的改善情况:复方苍耳子滴鼻剂高、低剂量组药前总评分与药后总评分比较差异有统计学意义(P<0.05),能显著性改善慢性鼻炎模型动物的整体症状;②对血清组胺含量的影响:复方苍耳子滴鼻剂高、低剂量组血清组胺含量均显著低于模型组(P<0.05或0.01),能显著降低慢性鼻炎模型动物的血清组胺含量;③形态组织学的改变:复方苍耳子滴鼻剂高、低剂量对鼻黏膜上皮化生、腺体增生、血管增生或扩张及炎性细胞等方面均能显著改善慢性鼻炎模型动物的形态组织学。结论复方苍耳子滴鼻剂对豚鼠实验性变态反应性鼻炎有显著的改善作用。

Effects of Xanthium sibiricum nasal drops on allergic rhinitis in guinea pigs

Objective To determine the effects of compound Xanthii sibiricum nasal drops on changes in symptoms and serum histamine level in allergic rhinitis guinea pig models. Methods The guinea pig nasal mucosal allergy model was established by using toluene-2,4-diisocyanate (2, 4-TDI) as a sensitizer. The level of histamine and morphohistological changes of each group were determined, with model group, positive drug group and blank control group regarded as controls. Results For nasal symptoms, both high and low dosage of compound Xanthii sibiricum nasal drops were associated with significant improvement in post-treatment total score when compared with pre-treatment levels (both P<0.05), suggesting marked recovery of overall symptoms in chronic rhinitis animal models. Both high and low dosage of compound Xanthii sibiricum nasal drops have, in terms of the impact on serum histamine lev el, resulted in considerably lower figures than model group (P<0.05 or 0.01), indicating significant attenuation of serum histamine in chronic rhinitis animal model. Additionally, both high and low dosage of compound Xanthii sibir icum nasal drops have led to morphohistological improvements with regard to epithelial metaplasia, hyperplasia of glands, vascular hyperplasia or dilatation as well as inflammatory cell counts in nasal mucosa. Conclusion Experimental allergic rhinitis in rats may benefit considerably from compound Xanthii sibiricum nasal drops treatment.