慢性阻塞性肺疾病并发呼吸衰竭相关危险因素分析

目的 探讨慢性阻塞性肺疾病(COPD)并发呼吸衰竭相关危险因素和预后因素.方法 对2005年3月至2008年2月收治的110例COPD患者的临床资料进行回顾性分析,根据是否发生呼吸衰竭分为呼吸衰竭组(40例)和非呼吸衰竭组(70例).结果 呼吸衰竭组每年急性发作次数、尿酸、总蛋白、白蛋白、体重指数与非呼吸衰竭组比较差异有统计学意义分别为(5.54±1.16)次/年比(2.75±0.78)次,年、(283.75±72.49)mmol/L比(359.87±41.50)mmol/L、(58.77±1.54)g/L比(63.95±2.04)g/L、(36.15±1.08)g/L比(36.96±1.48)g/L、(20.33±0.99)kg/m2比(21.16±1.36)kg/m2](P<0.01);COPD分度、院内感染、酸碱平衡紊乱两组比较差异有统计学意义(P<0.05或<0.01).呼吸衰竭死亡患者和好转患者动脉血氧分压比较差异无统计学意义(P>0.05),pH值、动脉血二氧化碳分压、血钠、血氯比较差异有统计学意义(P<0.01).结论 COPD并发呼吸衰竭相关危险因素多.

Analysis on relative risk factors of chronic obstructive pulmonary disease combined with respiratory failure

Objective To discuss relative risk factors and prognosis factors of chronic obstructive pulmonary disease (COPD) combined with respiratory failure.Methods Retrospective investigation was carried out to analyze the clinical data of 110 patients with COPD from March 2005 to February 2008.These patients were divided into two groups according to the condition of respiratory failure,respiratory failure group(40 cases) and non-respiratory failure group(70 cases).Results There were significant differences in the frequency of exacerbation,uric acid,total protein,albumin,bady-mass index between two groups (5.54 ± 1.16) times/year vs (2.75 ±0.78) times/year,(283.75 ±72.49) mmol/L vs (359.87 ±41.50)mmol/L,(58.77 ± 1.54) g/Lvs(63.95 ±2.04) g/L,(36.15 ± 1.08) g/L vs(36.96 ± 1.48) g/L,(20.33 ±0.99)kg/m2 vs (21.16 ± 1.36) kg/m2](P < 0.01).There were significant differences in COPD stage,nosocomial infection,acid-base disturbance between two groups(P< 0.05 or < 0.01).There was no statistical significance of partial pressure of oxygen in artery between the respiratory failure survival patients and dead patients (P >0.05).There were statistical significances in pH,partial pressure of carbon dioxide in artery,blood Na+,blood Cl-between the respiratory failure survival patients and dead patients (P< 0.01).Conclusion There are many relative risk factors of COPD combined with respiratory failure.