| Expression of CC Chemokine Ligand 20 and CC Chemokine Receptor 6 mRNA in Patients with Psoriasis Vuigaris |
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| 引用本文： | 吴艳,李家文. Expression of CC Chemokine Ligand 20 and CC Chemokine Receptor 6 mRNA in Patients with Psoriasis Vuigaris[J]. 华中科技大学学报(医学英德文版), 2004, 24(3): 297-299. DOI: 10.1007/BF02832019 |
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| 作者姓名： | 吴艳 李家文 |
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| 作者单位： | Department of Dermatology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Department of Dermatology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China |
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| 摘 要： | Itiswell knownthatimmune inflammatorymechanism playsanimportantroleinpsoriasis .Therelationshipbetweenchemokine ,receptorsandpsori asishasbeenconfirmed[1] .CCchemokineligand 2 0(CCL2 0 )isanewmemberinthefamilyof β chemokineandalsotheonlyligandofCCchemoki…
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| 关 键 词： | CC化学配合体20 基因表达 化学受体6 mRNA 牛皮癣 CCL20 |
| 收稿时间： | 2004-02-22 |
Expression of CC chemokine ligand 20 and CC chemokine receptor 6 mRNA in patients with psoriasis vulgaris |
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| Wu Yan,Li Jiawen. Expression of CC chemokine ligand 20 and CC chemokine receptor 6 mRNA in patients with psoriasis vulgaris[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2004, 24(3): 297-299. DOI: 10.1007/BF02832019 |
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| Authors: | Wu Yan Li Jiawen |
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| Affiliation: | Department of Dermatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China |
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| Abstract: | Summary In order to explore the possible role of CC chemokine ligand 20 (CCL20) and its receptor CC chemokine receptor 6 (CCR6) in the pathogenesis of psoriasis, the expression levels of mRNA of them in psoriatic lesions were investigated. The skin biopsies were collected from skin lesions in 35 cases of psoriasis vulgaris and 18 normal controls. RT-PCR was used to semi-quantitatively analyze the mRNA expression of CCL20 and CCR6 in the psoriatic lesions and the normal skin tissues. The results showed that the mRNA of CCL20 and CCR6 was present in every specimen. The expression levels of CCL20 mRNA in skin lesions were 1.1397±0.0521, which were greatly higher than those in normal controls (0.8681±0.0308) (P<0.001). The expression levels of CCR6 mRNA in skin lesions were 1.1103±0.0538, significantly higher than in the controls (0.9131±0.0433,P<0.001). These findings indicate that up-regulated expression of CCL20 and CCR6 mRNA might be related to the pathogenesis of psoriasis. WU Yan, female, born in 1975, Doctor in Charge |
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| Keywords: | psoriasis CC chemokine ligand 20 CC chemokine receptor 6 |
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