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Localization of dopamine and its relation to the growth hormone producing cells in the central nervous system of the snail Lymnaea stagnalis |
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| Authors: | T. R. Werkman J. van Minnen P. Voorn H. W. M. Steinbusch B. H. C. Westerink T. A. De Vlieger J. C. Stoof |
| Affiliation: | (1) Department of Neurology, Medical Faculty, Free University, van der Boechorstraat 7, 1081 BT Amsterdam, The Netherlands;(2) Department of Anatomy, Medical Faculty, Free University, van der Boechorstraat 7, 1081 BT Amsterdam, The Netherlands;(3) Department of Pharmacology, Medical Faculty, Free University, van der Boechorstraat 7, 1081 BT Amsterdam, The Netherlands;(4) Department of Neurophysiology, Biological Faculty, Free University, de Boelelaan 1087, 1081 HV Amsterdam, The Netherlands;(5) Pharmaceutical Laboratory, University of Groningen, Groningen, The Netherlands |
| Abstract: | Summary The distribution of dopamine in the central nervous system of the pond snail Lymnaea stagnalis was investigated by using immunocytochemistry and HPLC measurements. With both methods it was demonstrated that dopamine is predominantly present in the cerebral and pedal ganglia. The dopamine-immunoreactivity was mainly observed in nerve-fibers in the neuropile of the ganglia. Relatively few dopamine-immunopositive cell bodies (diameters 10–30  m) were found. A large cell in the right pedal ganglion (the so-called RPeD1) stained positively with the dopamine antibody. It has previously been demonstrated that the growth hormone producing cells (GHCs) possess dopamine receptors on their cell bodies. However, dopamine-immunopositive fibers were observed only in the vicinity of the GHC nerve-endings and not close to the GHC cell bodies. |
| Keywords: | Immunocytochemistry Dopamine Growth hormone producing cells Snail |
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