| N末端B型利钠肽原对单纯主动脉瓣关闭不全心力衰竭患者的诊断价值 |
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| 引用本文： | 吴超,杨跃进,赵雪燕,张健,黄洁,韦丙奇,孙寒松,王巍,闫鹏. N末端B型利钠肽原对单纯主动脉瓣关闭不全心力衰竭患者的诊断价值[J]. 中国循环杂志, 2011, 26(1). DOI: 10.3969/issn.1000-3614.2011.01.011 |
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| 作者姓名： | 吴超 杨跃进 赵雪燕 张健 黄洁 韦丙奇 孙寒松 王巍 闫鹏 |
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| 作者单位： | 1. 北京协和医学院,中国医学科学院,阜外心血管病医院,心内科,北京市,100037
2. 北京协和医学院,中国医学科学院,阜外心血管病医院,心外科,北京市,100037 |
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| 基金项目： | 北京市科委重大科技支撑项目 |
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| 摘 要： | 目的:评价N末端B型利钠肽原(NT-proBNP)对单纯主动脉瓣关闭不全(AR)心力衰竭患者的诊断价值.方法:使用酶联免疫的方法对27例单纯AR心力衰竭患者(单纯AR心力衰竭组)和76例正常对照者(正常对照组)行NT-pwBNP测定,评价其对单纯AR心力衰竭的诊断价值.结果:与正常对照组相比,单纯AR心力衰竭组的NT-pmBNP水平显著升高(P<0.05),差异有统计学意义;纽约心功能分级(NYHA)Ⅰ、Ⅱ级者差异无统计学意义;NYHA Ⅲ级者显著升高5.2倍,也显著高于NYHA Ⅰ、Ⅱ级者,差异均有统计学意义.在左心室舒张期末内径(LVEDD)>60 mm者显著高于LVEDD≤60 mm者(P<0.05),在合并心房颤动者也显著高于窦性心律者(P<0.01),差异均有统计学意义.当NT-proBNP阈值在1 340 pg/ml时,是诊断单纯AR心力衰竭(受试者工作特性曲线下面积=0.699,P<0.01)的最佳阈值;诊断的敏感性、特异性和准确性分别为59.26%、96.05%和86.41%.单因素分析,Los(NT-proBNP)仅与心功能(P=0.002)和LVEDD(P=0.033)呈显著正相关;多元逐步回归分析只有心功能与NT-pmBNP呈独立相关.结论:NT-proBNP对单纯AR心力衰竭患者有重要诊断价值.诊断单纯AR心力衰竭的最佳阈值为1 340 pg/ml,准确性高达86.41%.
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| 关 键 词： | 主动脉瓣关闭不全 心力衰竭 N末端B型利钠肽原 诊断 |
The Diagnostic Value of N-Terminal Pro-B Type Natriuretic Peptide in Aortic Regurgitation Patients With Heart Failure |
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| WU Chao,YANG Yue-jin,ZHAO Xue-yan,ZHANG Jian,HUANG Jie,WEI Bing-qi,SUN Han-song,WANG Wei,YAN Peng. The Diagnostic Value of N-Terminal Pro-B Type Natriuretic Peptide in Aortic Regurgitation Patients With Heart Failure[J]. Chinese Circulation Journal, 2011, 26(1). DOI: 10.3969/issn.1000-3614.2011.01.011 |
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| Authors: | WU Chao YANG Yue-jin ZHAO Xue-yan ZHANG Jian HUANG Jie WEI Bing-qi SUN Han-song WANG Wei YAN Peng |
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| Affiliation: | WU Chao,YANG Yue-jin,ZHAO Xue-yan,ZHANG Jian,HUANG Jie,WEI Bing-qi,SUN Han-song,WANG Wei,YAN Peng.Coronary Heart Disease Center,Cardiovascular Institute and Fu Wai Hospital,CAMS and PUMC,Beijing(100037),China |
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| Abstract: | Objective:To evaluate the diagnostic value of N-terminal pro-B type natriuretic peptide(NT-proBNP) in aortic regurgitation(AR)patients with heart failure.Methods:We summarized 27 AR patients with heart failure(Patient group) for blood level of NT-proBNP by ELISA,the patients were treated in our hospital from 2005 to 2006,and meanwhile,took 76 normal subjects as Control group.The diagnostic value of NT-proBNP for heart failure was assessed and compared in both groups.Results:Blood level of NT-proBNP was sign... |
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| Keywords: | Aortic regurgitation Heart failure N-terminal pro-B type natriuretic peptide Diagnosis |
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