电针对盐酸帕罗西汀治疗轻中度抑郁症患者起效时间及疗效的影响

目的 观察电针对盐酸帕罗西汀治疗轻、中度抑郁症患者的起效时间、疗效及汉密尔顿抑郁量表17项(HAMD)、抑郁自评量表(SDS)评分的影响.方法 将55例轻、中度抑郁症患者分为A组(盐酸帕罗西汀对照组)29例;B组(电针+盐酸帕罗西汀组)26例,疗程6周.观察治疗前及治疗1,2,4,6周后疗效及HAMD量表、SDS量表总评分变化情况.结果 A组治疗2周后,HAMD、SDS评分低于治疗前,差异有显著性意义(P＜0.05),B组在1周后,治疗前后比较差异有显著性(P＜0.05),A组HAMD评分总有效率71.4%,B组HAMD评分总有效率88.0%,两组间总有效率经单项有序卡方检验差异有显著性(X2=4.8041,P=0.0284,P＜0.05),SDS评分A组总有效率75.0%,B组总有效率84.0%,两组间总有效率经单项有序卡方检验差异有显著性(X2=4.1790,P=0.0408).结论 电针能够缩短帕罗西汀治疗轻中度抑郁症的起效时间且提高盐酸帕罗西汀治疗轻中度抑郁症的疗效.

Abstract：

Objective To observe the effect of electroacupuncture on onset time and effectiveness of Paroxetine for mild or moderate depression patients and on the scores of Hamilton depression rating scale for depression(HAMD) and self-rating depression scale(SDS). Methods Fifty-five patients with mild or moderate depression were randomly divided into A group( Paroxetine group,29 patients) and B group (Electroacupuncture combining with Paroxetine group,26 patients). Therapeutic periods for the two groups were 6 weeks. HAMD and SDS were used to evaluate the efficacy before the research and after treatment on 1 week,2 weeks,4 weeks,6 weeks.Results HAMD scores and SDS scores for A group were significant difference after 2 weeks treatment compared with the beginning of the research (P＜ 0.05 ) ;HAMD scores and SDS scores for B group were significant difference after 1 week treatment compared with the beginning of the research(P＜0. 05 ). Total effective rate of HAMD for A group was 71.4% ,total effective rate of SDS for A group was 75% ,total effective rate of HAMD for B group was 88% ,total effective rate of SDS for B group was 84%. The total effective rate between the two groups ordered by the individual chi-square test was significant difference( X2 = 4. 1790, P= 0. 0408). Conclusion Electroacupuncture can shorten the onset time and increase the effectiveness of paroxetine for mild or moderate depression patients.

Effect of electroacupuncture on therapeutic effects and onset time of paroxetine for mild or moderate depression patients

Objective To observe the effect of electroacupuncture on onset time and effectiveness of Paroxetine for mild or moderate depression patients and on the scores of Hamilton depression rating scale for depression(HAMD) and self-rating depression scale(SDS). Methods Fifty-five patients with mild or moderate depression were randomly divided into A group( Paroxetine group,29 patients) and B group (Electroacupuncture combining with Paroxetine group,26 patients). Therapeutic periods for the two groups were 6 weeks. HAMD and SDS were used to evaluate the efficacy before the research and after treatment on 1 week,2 weeks,4 weeks,6 weeks.Results HAMD scores and SDS scores for A group were significant difference after 2 weeks treatment compared with the beginning of the research (P＜ 0.05 ) ;HAMD scores and SDS scores for B group were significant difference after 1 week treatment compared with the beginning of the research(P＜0. 05 ). Total effective rate of HAMD for A group was 71.4% ,total effective rate of SDS for A group was 75% ,total effective rate of HAMD for B group was 88% ,total effective rate of SDS for B group was 84%. The total effective rate between the two groups ordered by the individual chi-square test was significant difference( X2 = 4. 1790, P= 0. 0408). Conclusion Electroacupuncture can shorten the onset time and increase the effectiveness of paroxetine for mild or moderate depression patients.