增强型体外反搏对高血压并糖耐量减低患者脉搏波传导速度及血管内皮功能的影响

目的探讨增强型体外反搏（EECP）治疗对高血压并糖耐量减低（IGT）患者肱踝脉搏波传导速度（b8PWV）及血管内皮功能的影响。方法38例高血压并IGT患者分为常规治疗组（CT，20例）和常规治疗＋EECP组（CT＋EECP，18例）。CT＋EECP组隔天反搏治疗2h，总共反搏36h，共36d。分别于体外反搏前和反搏后检测baPWV，同时检测血浆内皮素（ET）、一氧化氮（NO）.结果CT组和CT＋EECP组治疗后baPWV明显下降，分别为1703±213（P〈0．05）和1601±208（P〈0．01），两组比较差异有统计学意义（p〈0．05）.两组患者经治疗后ET均明显下降（74．8±21．3和62．6±20．8，P〈0．05，P〈0．01），NO均明显上升（67．7：1：17．4和78．2±18．2，P〈0．05，P〈0．01）.CT＋EECP组baPWV和ET下降更为显著，下降幅度与常规治疗组比较差异有统计学意义（P〈0．05）。结论增强型体外反搏可改善高血压并IGT患者血管内皮功能，降低血管僵硬度，从而改善动脉弹性。

The influences of enhanced external counterpulsation on pulse wave velocity and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance

Objective To explore the effect of Enhanced External Counterpulsation （EECP） on pulse wave velocity （baPWV） and vascular endothelial function in hypertensive patients complicated by impaired glucose tolerance （IGT）. Methods Thirty-eight hypertensive patients complicated by IGT were randomly divided into 2 groups ： the conventional therapeutics group （ CT, n =20 ）, the conventional therapeutics ＋EECP group （ CT＋EECP, n=18）. EECP was performed on CT＋EECP group, 2 hours every other day lasting for 36 days. baPWV, Plasma ET, Nitric oxide（NO） were measured at the same time points in all patients. Results In CT＋EECP group, baPWV was decreased significantly （1601±208, P〈0.01 ） after treatment comparing to the CT group （1703±213, P〈 0.05）. Level of endothelin（ET） was significantly decreased in CT＋EECP group （62.6±20.8, P〈0.01 ）, comparing to the CT group （74.8±21.3）mg/L, P〈0.05 ] after 36-day treatment. However, level of Nitric oxide（NO） was significantly improved in CT＋EECP group （78.2±18.2, P〈0.01） comparing to the CT group （67.7±17.4）mg/L, P〈 0.05） after treatment. Conclusion EECP could improve endothelial function and artery elasticity in hypertensive patients complicated by IGT.