更昔洛韦联合西米替丁治疗婴幼儿轮状病毒肠炎疗效观察

目的:探讨更昔洛韦联合西米替丁治疗婴幼儿轮状病毒肠炎的疗效。方法:将112例轮状病毒性肠炎患儿随机分为更昔洛韦组、更昔洛韦+西米替丁组和对照组三组。结果:治疗72h总有效率对照组、更昔洛韦组、更昔洛韦+西米替丁组分别为57.5%、87.5%、90.0%,更昔洛韦组、更昔洛韦+西米替丁组明显高于对照组(P<0.05或P<0.01);更昔洛韦+西米替丁组总有效率与更昔洛韦组比较差异无显著性意义(P>0.05),但显效率明显高于更昔洛韦组(P<0.05)。结论:更昔洛韦与西米替丁联合治疗婴幼儿轮状病毒肠炎疗效较好,值得临床应用。

The Effect of Ganciclovir and Cimetidine in Treatment of Infants Enteritis

Objective： To explore the effect of ganciclovir and cimetidine therapy on infants with rotavirus enteritis.Methods：112 infants with rotavirus enteritis were randomly divided into ganciclovir group, ganciclovir＋cimetidine group and control group. Results： The total effective rates of control group, ganciclovir group and ganciclovir＋cimetidine group in first 72 hours of the treatment were 57.5%, 87.5% and 90.0%. The total effective rates of ganciclovir group, ganciclovir＋cimetidine group were significantly higher than that of control group（P 〈0.05＆P 〈0.01）.There was no significant difference between ganciclovir＋cimetidine group and ganciclovir group（P 〉 0.05）, but the notable effective rates of the former group were significantly higher than that of ganciclovir group （P 〈0.05）.Conclusion： Ganciclovir and cimetidine in treating infants with rotavirus enteritis is effective.