| 细胞因子在造血干细胞移植中诱导免疫耐受的基础和应用研究 |
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| 引用本文： | 常英军,黄晓军. 细胞因子在造血干细胞移植中诱导免疫耐受的基础和应用研究[J]. 北京大学学报(医学版), 2009, 41(2): 208-211. DOI: 10.3969/j.issn.1671-167X.2009.02.018 |
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| 作者姓名： | 常英军 黄晓军 |
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| 作者单位： | （北京大学人民医院，北京大学血液病研究所， 北京100044） |
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| 基金项目： | 国家自然科学基金，国家教委跨世纪优秀人才计划基金，国家211工程学科建设项目，教育部高等学校博士学科点专项科研基金，卫生部科研基金，教育部教育振兴行动计划特殊专项(九工程) |
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| 摘 要： | 血液恶性疾病是严重危害人类生命健康的重大疾病,异基因造血干细胞移植(allogeneic hemopoietic stem cell transplantation,Allo-HSCT)是绝大多数血液恶性疾病患者的有效乃至唯一的根治手段,Allo-HSCT的基础是异体植入及随后的移植物抗白血病(graft versus leukemia,GVL)效应,但Allo-HSCT同时发生移植物抗宿主病(graft versus host disease,GVHD),导致GVHD相关死亡.
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| 关 键 词： | 细胞因子类 造血干细胞移植 免疫耐受 粒细胞集落刺激因子 |
Immune tolerance induced by cytokines in allogeneic hematopoietic stem cell transplantation |
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| CHANG Ying-jun,HUANG Xiao-jun. Immune tolerance induced by cytokines in allogeneic hematopoietic stem cell transplantation[J]. Journal of Peking University. Health sciences, 2009, 41(2): 208-211. DOI: 10.3969/j.issn.1671-167X.2009.02.018 |
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| Authors: | CHANG Ying-jun HUANG Xiao-jun |
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| Affiliation: | CHANG Ying-jun,HUANG Xiao-jun(Peking University People's Hospital & Peking University Institute of Hematology,Beijing 100044,China) |
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| Abstract: | Allo-HSCT is a potentially curative therapy for many hematological malignancies,the basis of which is graft-versus-leukemia(GVL) effect.However,acute graft-versus-host disease(GVHD) is responsible for 15% to 40% of mortality and is the major cause of morbidity after transplantation.Therefore,separation of GVHD and GVL partially or completely could improve the transplant outcomes.This study focuses on the effects of G-CSF on T cells in peripheral blood stem cell grafts and bone marrow grafts and its mechanis... |
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| Keywords: | Cytokines Hematopoietic stem cell transplantation Immune tolerance Granulocyte colony-stimulating factor |
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