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| 东菱克栓酶对大鼠急性肠系膜微动脉血栓溶栓作用的实验研究 | |
| 引用本文： | 耿昱,陈怀红,郑筱祥,徐蕾,丁德云.东菱克栓酶对大鼠急性肠系膜微动脉血栓溶栓作用的实验研究[J].中国微循环,1999,3(2):99-101. |
| 作者姓名： | 耿昱 陈怀红 郑筱祥 徐蕾 丁德云 |
| 作者单位： | 1. 310016,浙江省杭州市,浙江大学附属邵逸夫医院神经内科 2. 浙江大学生命科学与医学工程学系 3. 浙江大学附属第二医院神经内科 |
| 摘 要： | 目的 探讨东菱克栓酶（ＤＦ－５２１）对在鼠肠系膜微动脉血栓的溶栓时间和机制。方法 采用光化学诱导法和静脉注射荧光素钠制作大鼠肠系膜微动脉血栓模型，经显微电视摄像系统和多媒体计算机图像处理技术相结合，定量分析不同剂量组ＤＦ－５２１的溶栓时间以及血管再通程度。 |
| 关 键 词： | 东菱克栓酶 微动脉血栓 肠系膜 溶栓治疗 |
Experimental Study on Effects of Batroxobin (DF-521) in Treating Microartery Thrombosis of Rat Mesentery |
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| Gen Yu,Chen Huaihong,Zhen Xiaoxiang,et al Shao Yifu Hospital Affiliated to Zhejiang University,Hangzhou.Experimental Study on Effects of Batroxobin (DF-521) in Treating Microartery Thrombosis of Rat Mesentery[J].Journal of Chinese Microcirculation,1999,3(2):99-101. | |
| Authors: | Gen Yu Chen Huaihong Zhen Xiaoxiang Shao Yifu Hospital Affiliated to Zhejiang University Hangzhou |
| Institution: | Gen Yu,Chen Huaihong,Zhen Xiaoxiang,et al Shao Yifu Hospital Affiliated to Zhejiang University,Hangzhou 310016 |
| Abstract: | Objective To evaluate the duration and the mechanism of batroxobin (DF-521) in treating microarterythrombosis of rat mesentery.Methods Microarterythrombus formation model was made by the filtered light irradiation and intravascular fluorescein sodium administration,the duration and extent of recanalization in different dosagegroups were measured using computer image subtraction. Results The mean time of recanalization is 26.7?. 4min in 8U/kg group and 45?3.6min in 16U/kg group respectively,the reocclusion doesn't happen when the caliber of the recanalization is over 25% of the diameter of the microartery.Conclusion Batroxobin shows a good curative effect on microarterythrombus of rat mesentery. |
| Keywords: | Batroxobin(DF-521) Microartery Thrombosis Rat |
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