| 黄芪对广防己中马兜铃酸与粉防己中粉防 己碱含量的影响研究 |
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| 引用本文： | 梁琦,张艳霞,许刚,倪诚,谢鸣.黄芪对广防己中马兜铃酸与粉防己中粉防 己碱含量的影响研究[J].中国实验方剂学杂志,2012,18(2):111-114. |
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| 作者姓名： | 梁琦 张艳霞 许刚 倪诚 谢鸣 |
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| 作者单位： | 1. 山西中医学院国家中医药管理局重点学科方剂学,太原,030024
2. 北京中医药大学国家重点学科方剂学,北京,100029 |
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| 基金项目： | 国家自然科学基金项目(30572299);山西省教育厅科技项目(20101107) |
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| 摘 要： | 目的:从化学角度探查黄芪对广、粉防己的影响机制.方法:采用HPLC法测定广防己及其配伍黄芪水提物中马兜铃酸含量；粉防己及其配伍黄芪水提物中粉防己碱的含量.结果:广防己和广防己配伍黄芪水提物中马兜铃酸转移率分别为86.21％,51.86％；粉防己和粉防己配伍黄芪水提物中粉防己碱转移率分别为56.45％,63.03％.结论:广防己中的马兜铃酸和粉防己中的粉防己碱在水提过程中均有损耗,其配伍黄芪则分别增加和减少马兜铃酸和粉防己碱的溶出率.该结果为黄芪与广、粉防己配伍的减毒、增效作用提供了一定的理解,提示复方汤药制备对药物不同成分溶出的影响是中药配伍机制的重要环节之一.
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| 关 键 词： | 马兜铃酸 粉防己碱 广防己 粉防己 中药配伍 |
| 收稿时间： | 2011/9/19 0:00:00 |
Astragali Radix Influence on the Content Changes of Aristolochic Acid in Aristolochiae Fangchi and Tet in Stephania Tetrandra |
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| LIANG Qi,ZHANG Yan-xi,XU Gang,NI Cheng and XIE Ming.Astragali Radix Influence on the Content Changes of Aristolochic Acid in Aristolochiae Fangchi and Tet in Stephania Tetrandra[J].China Journal of Experimental Traditional Medical Formulae,2012,18(2):111-114. |
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| Authors: | LIANG Qi ZHANG Yan-xi XU Gang NI Cheng and XIE Ming |
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| Institution: | Department of Formulaology, Shanxi University of Chinese Medicine, Taiyuan 030024, China;Department of Formulaology, Beijing University of Chinese Medicine, Beijing 100029, China;Department of Formulaology, Beijing University of Chinese Medicine, Beijing 100029, China;Department of Formulaology, Beijing University of Chinese Medicine, Beijing 100029, China;Department of Formulaology, Beijing University of Chinese Medicine, Beijing 100029, China |
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| Abstract: | Objective: To study the chemical mechanism of Astragali Radix influence on Aristolochiae Fangchi and Stephania Tetrandra. Method: Aristolochic acid(AA) in aqueous extract of Aristolochiae Fangchi combined with Astragali radix and Tet in the aqueous extract of Stephania Tetrandra combined with Astragali Radix were determined by the method of HPLC. Result: The transfer rate of AA was 86.21% and 51.86% separately in aqueous extract of Aristolochiae fangchi and combined with Astragali Radix. The transfer rate of Tet was 56.45% and 63.03% separately in aqueous extract of Stephania Tetrandra and combined with Astragali Radix. Conclusion: The AA and Tet were all lose in the process of water extract. Matching that Astragali radix could decrease the dissolution rate of AA and increase the dissolution rat of Tet. |
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| Keywords: | aristolochic acid tetrandrine aristolochia fangchi Stephania Tetrandra compatibility |
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