小剂量维生素E、维生素C和肠溶阿司匹林对超氧化物歧化酶及其同功酶的影响

目的：对比观察肠溶阿司匹林、维生素E（VitE)、维生素C（VitC）3药合用与后两者合用，对超氧化物歧化酶（Sod）及其同功酶的影响。方法：将51例高血压患者、28例无合并症的冠心病患者，以及30例健康人群随机抽样各分为两组，观察服药前和服药后3年与5年的Sod及其同功酶的变化。结果：（1）总Sod活力及其同功酶的活力随高血压的病情加重而明显降低，与健康人群比较有显著性差异。（2）VitE和VitC合用可使Sod及其同功酶逐渐升高，与服药前比较有统计学差异（P＜0．05）。（3）3药合用升高更明显，与2药合用比较有极显著性差异（P＜0．01）；与服药前比较也有极显著性差异（P＜0．01）。（4）服药后3年与5年比较无显著性差异。结论：3药合用的抗衰老作用优于2药合用；口服小剂量肠溶阿司匹林、VitE和VitC的时间不应短于3年。

The Effects of Lower-dosage Vitamin E, Vitamin C and Enteric-coated Aspirin on Superoxide Dismutase and lts lsozymes

Objective: To compare the combination therapeutic effects of three drugs (Vitamin E, Vitamin C enteric-coated Aspirin) with two drugs (Vitamin E, Vitamin C) on superoxide dismutase (SOD) and its isozymes. Methods: Fifty-one patients with hypertension, 28 patients with coronary heart disease, and 30 healthy people were randomly divided into two groups respectively, and were treated with three or two drugs. The therapeutic effects on SOD and its isozymes were measured before and 3, 5 years aftes treatment. Results: (1) The activity og total SOD and its isozymes significantly decreased with the deterioration of hypertension, which had a significant difference compared with healthy people. (2) The level of SOD and its isozymes gradually increased by the treatment of Vitamin E and Vitamin C, which had a statistical difference compared with pre treatment (P<0.05). The increase of SOD and its isozymes was more significant in people with three drugs, which had a significant difference compared with two drugs and pre treatment (P<0.01). (3) There was no significant therapeutic difference between three and five years after treatment. Conclusion: The anti-ageing effect of combination treatment with three drugs was better than that of two drugs. The therapeutic time with the treatment of Vitamin E, Vitamin C and enteric-coated aspirin should not be shorter than three years.