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| 内侧颞叶癫痫自我参照加工受损的功能磁共振成像 | |
| 引用本文： | 袁翠平,张志强,王正阁,张浩,谭启富,陈光辉,卢光明.内侧颞叶癫痫自我参照加工受损的功能磁共振成像[J].中国医学影像技术,2011,27(3):495-499. |
| 作者姓名： | 袁翠平 张志强 王正阁 张浩 谭启富 陈光辉 卢光明 |
| 作者单位： | 1. 南京军区南京总医院医学影像科,江苏,南京,210002 2. 南京军区南京总医院神经外科,江苏,南京,210002 3. 南京军区南京总医院神经内科,江苏,南京,210002 |
| 基金项目： | 国家自然科学基金(30800264、30971019)、南京军区重点医药卫生项目(07z030)、南京军区南京总医院基金项目(Q2008063)、江苏省博士后基金项目(0801033)。 |
| 摘 要： | 目的 采用功能磁共振成像(fMRI)技术对内侧颞叶癫痫(mTLE)患者的自我参照功能受损状况进行评价。方法 12例伴有海马硬化的mTLE患者及15名健康志愿者纳入本研究。采用内向诱导与外向诱导任务,以内向诱导任务为刺激状态、外向诱导任务为控制状态,收集fMRI数据,观察mTLE患者自我参照加工相关脑区反应的改变。结果 与健康志愿者相比,mTLE患者的内侧前额叶、扣带回前部及后部等与自我参照加工相关的区域活动明显降低(P＜0.01)。结论 mTLE患者以内侧前额叶为主的自我参照加工脑区活动降低,反映其与自我参照加工相关的高级脑认知功能损伤,是mTLE患者异常影像表现的病理生理学基础。 |
| 关 键 词： | 癫痫 颞叶 磁共振成像 心理过程 |
| 收稿时间： | 2010/7/29 0:00:00 |
| 修稿时间： | 2010/8/15 0:00:00 |
Impaired self-referential processing in medial temporal lobe epilepsy revealed with functional MRI |
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| YUAN Cui-ping,ZHANG Zhi-qiang,WANG Zheng-ge,ZHANG Hao,TAN Qi-fu,CHEN Guang-hui and LU Guang-ming.Impaired self-referential processing in medial temporal lobe epilepsy revealed with functional MRI[J].Chinese Journal of Medical Imaging Technology,2011,27(3):495-499. | |
| Authors: | YUAN Cui-ping ZHANG Zhi-qiang WANG Zheng-ge ZHANG Hao TAN Qi-fu CHEN Guang-hui and LU Guang-ming |
| Institution: | Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Neurosurgery, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Neurology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China;Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China |
| Abstract: | Objective To assess the extent of impairment of self-referential processing in medial temporal lobe epilepsy(mTLE) with functional magnetic resonance imaging(fMRI).Methods Twelve mTLE patients with hippocampal sclerosis and 15 healthy volunteers were enrolled.The self-reference activation was induced by contrast of the imternally cued condition and externally cued condition in a block-designed fMRI task.The fMRI data were acquired.The changes of self-referential processing relevant encephalic region in mTLE... |
| Keywords: | Epilepsy temporal lobe Magnetic resonance imaging Mental processes |
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