The intron 4c allele of the NOS3 gene is associated with ischemic stroke in African Americans |
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| Authors: | RP Grewal AVC Dutra Yi C Liao Ss H Juo NIH Papamitsakis |
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| Institution: | (1) New Jersey Neuroscience Institute at JFK Medical Center, 65 James Street, 08818 Edison, NJ, USA;(2) Graduate Institute of Medicine, Kaohsiung Medical University, 800 Kaohsiung, Taiwan;(3) Department of Neurology, Kaohsiung Medical University Hospital, 800 Kaohsiung, Taiwan;(4) Department of Neurology, Medical University of South Carolina, 96 Jonathan Lucas Street, 29425 Charleston, SC, USA |
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| Abstract: | Background Ischemic stroke is the most common cause of disability in North America and in addition to the generally accepted risk factors,
there is increasing evidence for the potential pathophysiological role of genes. One of these genes, the endothelial nitric
oxide synthase gene (NOS3) has been reported as a genetic risk factor for ischemic stroke. To independently confirm and extend the results of these
previous reports, we investigated this gene as a risk factor for stroke in an ethnically diverse study population. |
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